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首页> 外文期刊>Physiological Reviews >Inositol trisphosphate receptor Ca2+ release channels.
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Inositol trisphosphate receptor Ca2+ release channels.

机译：肌醇三磷酸受体Ca2 +释放通道。

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The inositol 1,4,5-trisphosphate (InsP3) receptors (InsP3Rs) are a family of Ca2+ release channels localized predominately in the endoplasmic reticulum of all cell types. They function to release Ca2+ into the cytoplasm in response to InsP3 produced by diverse stimuli, generating complex local and global Ca2+ signals that regulate numerous cell physiological processes ranging from gene transcription to secretion to learning and memory. The InsP3R is a calcium-selective cation channel whose gating is regulated not only by InsP3, but by other ligands as well, in particular cytoplasmic Ca2+. Over the last decade, detailed quantitative studies of InsP3R channel function and its regulation by ligands and interacting proteins have provided new insights into a remarkable richness of channel regulation and of the structural aspects that underlie signal transduction and permeation. Here, we focus on these developments and review and synthesize the literature regarding the structure and single-channel propertiesof the InsP3R.
机译：肌醇1,4,5-三磷酸（InsP3）受体（InsP3Rs）是Ca2 +释放通道家族，主要位于所有细胞类型的内质网中。它们起着响应多种刺激产生的InsP3的作用，将Ca2 +释放到细胞质中，产生复杂的局部和全局Ca2 +信号，调节从基因转录到分泌到学习和记忆的多种细胞生理过程。 InsP3R是钙选择性阳离子通道，其选通不仅受InsP3调节，还受其他配体（特别是细胞质Ca2 +）调节。在过去的十年中，对InsP3R通道功能及其通过配体和相互作用蛋白进行调节的详细定量研究提供了对通道调节显着丰富以及信号转导和渗透基础的结构方面的新见解。在这里，我们关注这些发展，并回顾和综合有关InsP3R的结构和单通道特性的文献。

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