Regulatory Binding Partners and Complexes of NHE3.

Donowitz M; Li X

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Regulatory Binding Partners and Complexes of NHE3.

机译：NHE3的调控结合伴侣和复合物。

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NHE3 is the brush-border (BB) Na(+)/H(+) exchanger of small intestine, colon, and renal proximal tubule which is involved in large amounts of neutral Na(+) absorption. NHE3 is a highly regulated transporter, being both stimulated and inhibited by signaling that mimics the postprandial state. It also undergoes downregulation in diarrheal diseases as well as changes in renal disorders. For this regulation, NHE3 exists in large, multiprotein complexes in which it associates with at least nine other proteins. This review deals with short-term regulation of NHE3 and the identity and function of its recognized interacting partners and the multiprotein complexes in which NHE3 functions.

机译：NHE3是小肠，结肠和肾近端小管的刷状边界（BB）Na（+）/ H（+）交换子，涉及大量中性Na（+）吸收。 NHE3是高度调控的转运蛋白，其通过模拟餐后状态的信号被刺激和抑制。它在腹泻疾病以及肾脏疾病的变化中也会下调。对于这种调节，NHE3存在于大型的多蛋白复合物中，在其中它与至少九种其他蛋白缔合。这篇综述涉及NHE3的短期调节及其公认的相互作用伙伴以及NHE3在其中起作用的多蛋白复合物的身份和功能。

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《Physiological Reviews》 |2007年第3期|共48页
作者
Donowitz M; Li X;
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原文格式 PDF
正文语种 eng
中图分类人体生理学;
关键词
Sodium measurement; binding; Renal; Membrane Transport Proteins;

机译：钠盐测定;结合;肾;膜转运蛋白;

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1. Regulatory Binding Partners and Complexes of NHE3. [J] . Donowitz M, Li X Physiological Reviews . 2007,第3期

机译：NHE3的调控结合伴侣和复合物。
2. The DNA-binding defect observed in major histocompatibility complex class II regulatory mutants concerns only one member of a family of complexes binding to the X boxes of class II promoters. [J] . C Herrero Sanchez, W Reith, P Silacci, Molecular and Cellular Biology . 1992,第9期

机译：在主要的组织相容性复合物II类调节突变体中观察到的DNA结合缺陷仅涉及与II类启动子X盒结合的复合物家族中的一个成员。
3. Binding partners of NRF2: Functions and regulatory mechanisms [J] . Nam Le Ba, Keum Young-Sam Archives of Biochemistry and Biophysics . 2019,第期

机译：NRF2的绑定伙伴：功能和监管机制
4. REGULATORY INTERACTIONS INVOLVED IN NITROGEN SIGNALLING IN CYANOBACTERIA: PARTNER SWAPPING AND ROLE OF PIPX-PH COMPLEXES IN SYNECHOCOCCUS SP. PCC 7942 [C] . J. Espinosa, M. A. Castells, K. Forchhammer, International Conference of the African Association for Biological Nitrogen Fixation . 2008

机译：Cyanobacteria中氮信号中涉及的调节相互作用：合作伙伴交换和PiPx-pH复合物在SyneChococcus sp中的作用。 PCC 7942.
5. Identifying protein-protein binding sites and binding partners using sequence and structure information. [D] . Chung, Jo-Lan. 2007

机译：使用序列和结构信息识别蛋白质-蛋白质结合位点和结合伴侣。
6. The DNA-binding defect observed in major histocompatibility complex class II regulatory mutants concerns only one member of a family of complexes binding to the X boxes of class II promoters. [O] . C Herrero Sanchez, W Reith, P Silacci, 1992

机译：在主要的组织相容性复合物II类调控突变体中观察到的DNA结合缺陷仅涉及与II类启动子X盒结合的复合物家族中的一个成员。
7. The DNA-binding defect observed in major histocompatibility complex class II regulatory mutants concerns only one member of a family of complexes binding to the X boxes of class II promoters [O] . Herrero Sanchez, Carlos, Reith, Walter, Silacci, P., 1992

机译：在主要组织相容性复合物II类调控突变体中观察到的DNA结合缺陷仅涉及与II类启动子X盒结合的复合物家族中的一个成员

Regulatory Binding Partners and Complexes of NHE3.

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