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首页> 美国政府科技报告 >Isolation and Structure of the Cell Growth Inhibitory Constituents from theWestern Pacific Marine Sponge Axinella sp
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Isolation and Structure of the Cell Growth Inhibitory Constituents from theWestern Pacific Marine Sponge Axinella sp

机译：西太平洋海绵axinella sp。细胞生长抑制成分的分离和结构

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While isolation of alkaloids from marine Porifera has been accelerating, only asmall number of antineoplastic or peptide constituents have been recovered from these invertebrates. Our isolation and structural determination of the P388 lymphocytic leukemia (PS system) cell growth inhibitory cyclooctapeptide hymenistatin from a Palau sponge in the genus Hymeniacidon represented the first such combination of source, structural type, and biological activity. We have also found an Axinella sp. (Demospongiae class) collected (in 1979) in Palau (at -40m) to yield a methylene chloride 2 propanol extract that provided a 101% increase in life span (at 100 mg/kg) against the PS leukemia with ED50 2.5 mg/ml in the corresponding cell line. In 1985 the sponge was recollected (Palau) and preserved in 2 propanol. A 220-kg (wet weight) portion was extracted with methylene chloride methanol. By means of PS guided bioassay and a series of detailed solvent partition, gel permeation (and gel partition, Sephadex LH-20), partition (silica gel including reversed phase), and adsorption column chromatographic techniques, a series of structurally diverse antineoplastic constituents was detected in this very productive sponge.

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