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首页> 美国政府科技报告 >Temporally-Specific Modification of Myelinated Axon Excitability In vitroFollowing a Single Ultrasound Pulse
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Temporally-Specific Modification of Myelinated Axon Excitability In vitroFollowing a Single Ultrasound Pulse

机译：单个超声脉冲在体外对髓鞘轴突兴奋性的时间特异性修饰

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Single, short duration, low energy pulses of ultrasound were found to elicitdistinct modifications of the electrical excitability of myelinated frog sciatic nerve in vitro in a window extending 40-50 ms after pulse termination. These modifications include both enhancement and suppression of relative excitability, the sequence of which generally follows one of two distinct temporal response patterns. The ultrasound pulses were focused, 2.7 MHz, of 500 duration, and of peak intensities of 100-800 W/sq cm. Total absorbed pulse energies were generally less than 100 mJ/g. corresponding to local temperature rises of the nerve trunk of no more than 0.025 C per pulse, thereby precluding bulk heating as a basis of this effect. The observed effects cannot be elicited using either a subthreshold square wave or RF electrical prestimulus, suggesting a unique form of receptivity of the nerve trunk to mechanical perturbation. We present evidence that the low-frequency radiation pressure transient accompanying the envelope of the acoustic pulse is the active parameter in this phenomenon, and postulate that it may act by the gating of stretch sensitive channels, which have been recently reported i a variety of cell membranes. These results may demonstrate that stretch sensitive channels in neural membrane could serve to functionally modulate neuro electric signals normally mediated by voltage dependent channels, a finding which could suggest new clinical applications of high peak power, low total energy pulsed ultrasound.

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