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首页> 美国政府科技报告 >Primary Dermal Irritation Potential of Physostigmine Salicylate, PhysostigmineFree-Base, and Pyridostigmine Bromide in New Zealand White Rabbits~8 Dec 87-13 Jan 88
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Primary Dermal Irritation Potential of Physostigmine Salicylate, PhysostigmineFree-Base, and Pyridostigmine Bromide in New Zealand White Rabbits~8 Dec 87-13 Jan 88

机译：新西兰白兔中毒扁豆碱水杨酸盐，毒扁豆碱，碱基和吡啶斯的明溴化物的原代皮肤刺激作用〜8月8日87-13 Jan 88

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Physostigmine salicylate is being considered by the U.S. Army Medical Researchand Development Command as a replacement for pyridostigmine bromide in treatment regimens which protect soldiers from nerve agent toxicity/lethality. The primary dermal irritation potentials of physostigmine salicylate, physostigmine free-base, and pyridostigmine bromide were determined in male New Zealand White rabbits by using a modified Draize method. Each test compound was applied to two sites on the backs of a group of rabbits for a 4-hour period. Exposure sites were evaluated for erythema and edema at approximately 1, 24, 48, and 72 hours after removal of the test material. No skin reactions attributable to physostigmine salicylate were detected at any time during the 14-28 day observation periods. One animal in group 1 treated with pyridostigmine exhibited very slight erythema in one of the two test compound quadrants. One animal in group 3 also exhibited slight erythema in one of the two quadrants after exposure to physostigmine free-base. Of the animals in group 4 that were exposed to all three test compounds, the only reaction observed occurred in one animal that exhibited very slight erythema at the pyridostigmine test site. Physostigmine salicylate, physostigmine free-base, and pyridostigmine bromide were nonirritants under conditions of this study. Keywords: toxicity, Antidotes. (aw)

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