• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国政府科技报告 >The Interaction of Pseudomonas Toxins with Epithelial Cell Membranes; The Primary Step in the Pathogenetic Sequence of Cellular Intoxication
【24h】

The Interaction of Pseudomonas Toxins with Epithelial Cell Membranes; The Primary Step in the Pathogenetic Sequence of Cellular Intoxication

机译：假单胞菌毒素与上皮细胞膜的相互作用;细胞中毒病原学序列的主要步骤

获取原文
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

During the past year, we have found: (i) how the electrical characteristics of the apical membrane of the turtle bladder epithelium are changed after exposure to each of three extracellularly-added, ADPR transferase containing bacterial toxins (e.g., the proenzymatic form of Pseudomonas toxin A, Cholera enterotoxin and Diphtheria toxin); (ii) how to segregate the apical from the basal-lateral membranes, how to identify each kind of membrane by uniquely-located enzymatic markers (e.g., ouabain-sensitive ATPase and a DIDS-binding protein mark the basal-lateral membrane; while a catecholamine-sensitive adenylate cyclase, a cyclic nucleotide-sensitive phosphoprotein kinase, and a concanavalin A-binding glycoprotein mark the apical membrane); and (iv) In recent preliminary experiments, we have found that the transport-stimulating effect of cholera toxin is eliminated when this transport has been pre-stimulated with norepinephrine; and conversely, the stimulatory effect of norepinephrine cannot be evoked when the transport parameter has been pre-stimulated with cholera toxin.

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号