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Ester Synthesis from Inosine, Deoxyinosine, and Ribose-5-Phosphate in Human Erythrocyte Chosts

机译：人红细胞中肌苷，脱氧肌苷和核糖-5-磷酸酯的酯合成

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Pathways for the conversion of pentoses to hexoses were studied in ghosts with inosine, deoxyinosine, and ribose-5phosphate as substrates. Inosine and ribose-5-phosphate were qualitatively similar in the synthesis of ketopentosephosphates, triosephosphates, and hexosephosphates. Quantitative differences in turnover rates were found to be dependent on the substrate concentrations of esters incubated. With inosine a hexose to triose ratio of 2:1 was observed at equilibration, while a ratio of 1:1 was found with ribose-5phosphate. Hexose synthesis, apparently inhibited at high ribose-5-phosphate concentrations, is explained as a displacement of donor fructose-6-phosphate by acceptor ribose5-phosphate in the bimolecular reaction with the enzyme transaldolase. This acted to stimulate the production of trioses. Phosphoglycerate and lactic acid synthesis also exhibited different kinetic characteristics for both inosine and ribose-5-P. Both phosphoglycerates and lactate increased kinetically with inosine and decreased with ribose-5-P. The data suggest that a pathway from ribose-5-phosphate to phosphoglycerates exists in the erythrocyte. (Author)

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Lionetti, F. J.;
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年度 1964
页码 p.1-2
总页数 2
原文格式 PDF
正文语种 eng
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关键词
ERYTHROCITES ; ESTERS ; METABOLISM ; BIOSYNTHESIS ; PENTOSES ; HEXOSES ; RIBOSE ; FRUCTOSE ; ENZYMES ; PHOSPHOROUS COMPOUNDS ; LACTIC ACID ; NUCLEOSIDES ; GLYCOLYSIS ; PHOSPHORYLATION ; CARBOHYDRATES ; PHOSPHORUS COMPOUNDS ; BLOOD CELLS ; VIABILITY ; BIOCHEMISTRY;

机译：红细胞;酯;代谢;生物合成; pENTOsEs; HEXOsEs; RIBOsE;果糖;酶;磷化合物;乳酸;核苷;糖解;磷酸化;碳水化合物;磷化合物;血细胞;活力;生物化学;

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1. Lipase-catalyzed protection of the hydroxy groups of the nucleosides inosine and 2'-deoxyinosine: a new chemoenzymatic synthesis of the antiviral drug 2',3'-dideoxyinosine. [J] . Ciuffreda P, Casati S, Santaniello E Bioorganic and Medicinal Chemistry Letters . 1999,第11期

机译：脂肪酶催化的核苷肌苷和2'-脱氧肌苷的羟基保护：抗病毒药2'，3'-二脱氧肌苷的新化学合成。
2. Volumetric Properties at High Pressures of the Nucleosides Inosine, 2'-Deoxyinosine, and 2'-Deoxyguanosine and the Volumetric Properties of Guanosine Derived Using Group Additivity Methods [J] . Gavin R. Hedwig, Geoffrey B. Jameson, Harald Holland Journal of Chemical and Engineering Data: the ACS Journal for Data . 2014,第11期

机译：核苷肌苷，2'-脱氧肌苷和2'-脱氧鸟苷的高压体积特性以及使用基团加和法得到的鸟苷的体积特性
3. The Partial Molar Heat Capacities and Expansions of Inosine, 2 '-Deoxyinosine and 2 '-Deoxyguanosine in Aqueous Solution at 298.15 K [J] . Hedwig GR Journal of Solution Chemistry . 2009,第10期

机译：298.15 K下水溶液中肌苷，2'-脱氧肌苷和2'-脱氧鸟苷的部分摩尔热容和膨胀
4. Synthesis of Inosine Polyphosphates from Inosine 5'-phosphate [C] . Jian Sun, Shan-Shan Gong, Qi Sun International Conference on Environmental Science and Material Application . 2014

机译：Inosine 5'-磷酸氨基磷酸酯的合成
5. Design, synthesis and biological evaluation of human inosine 5'-monophosphate dehydrogenase inhibitors: 1,5-diazabicyclo(3.1.0)hexane-2,4-diones, as novel isozyme-selective cancer chemotherapeutic agents. [D] . Barnes, Betsy Jo. 1999

机译：人肌苷5'-单磷酸脱氢酶抑制剂的设计，合成和生物学评估：1,5-二氮杂双环（3.1.0）己烷-2,4-二酮，作为新型的同工酶选择性癌症化学治疗剂。
6. PHOSPHORYLATED CARBOHYDRATE INTERMEDIATES OF THE HUMAN ERYTHROCYTE DURING STORAGE IN ACID CITRATE DEXTROSE. III. EFFECT OF INCUBATION AT 37° C WITH INOSINE INOSINE PLUS ADENINE AND ADENOSINE AFTER STORAGE FOR 6 10 14 AND 18 WEEKS [O] . A. William Shafer, Grant R. Bartlett 1962

机译：酸性柠檬酸溶液中储存过程中人类红细胞的磷酸化碳水化合物中间体。三储存6、10、14和18周后肌苷肌苷加腺嘌呤和腺苷在37°C孵育后的效果
7. Pharmacokinetic properties of a novel inosine analog, 4′-cyano-2′-deoxyinosine, after oral administration in rats [O] . Mai Hashimoto, Kazuaki Taguchi, Takako Ishiguro, 2018

机译：大鼠口服施用后新型Inosine类似物，4'-氰基-2'-脱氧酶的药代动力学性质
8. Synthesis of Adenosine Nucleotides from Hypoxanthine by Human Malaria Parasites (Plasmodium falciparum) in Continuous Erythrocyte Culture: Inhibition by Hadacidin but not Alanosine [R] . Webster, H. K., Whaun, J. M., Walker, M. D., 1984

机译：人疟疾寄生虫（恶性疟原虫）在连续红细胞培养中从次黄嘌呤合成腺苷核苷酸：Hadacidin但不是丙氨酸的抑制

Ester Synthesis from Inosine, Deoxyinosine, and Ribose-5-Phosphate in Human Erythrocyte Chosts

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