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Bioinformatic Approach to Inter Functional Interactions within Protein Sequences

机译：蛋白质序列内相互功能相互作用的生物信息学方法

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The primary purpose of the current project was to evaluate the techniques they had developed to infer functional interactions between the sites within a protein and, if appropriate, refine them in the light of the results of evaluation. The initial results revealed significant limitations of their preliminary approaches. As a result of this project, it is now apparent that deep understanding of the significance of co-evolution between sites within a protein family requires sophisticated methods for identifying large groups of co-evolving sites, in some cases more than 100 sites that all co- evolve with one another. They have developed techniques that first identify all pairs of co-evolved sites and then identify all maximal cliques that can be formed from these pairs. In the process they developed a new data mining technique, association networks. In a separate study they have applied their approaches to the problem of whole genome alignment. They have successfully developed an engine that can align whole genomes and are extending it to handle the case of sequence reordering.

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作者
Webb, G. I.; Whisstock, J. C.;
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年度 2009
页码 p.1-50
总页数 50
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Proteins; Biomedical information systems; Sequences; Interactions; Information retrieval; Genome; Australia; Networks; Biology; Methodology; Data processing;

机译：蛋白质;生物医学信息系统;序列;相互作用;信息检索;基因组;澳大利亚;网络;生物学;方法学;数据处理;

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3. The Interactions of the Largest Subunit of RNA Polymerase II with Other Cellular Proteins: a Bioinformatic Approach [J] . Shukla A, Bhaumik S, Lightfoot D Current Issues in Molecular Biology . 2009,第Supplaa1期

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5. Prediction of protein structures and protein-protein interactions: A bioinformatics approach. [D] . Chen, Huiling. 2005

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6. Identification Of Novel Functional Regions Within The Spike Glycoprotein OfMHV-A59 Based On A Bioinformatics Approach [O] . Gili Kaufman, Pinghua Liu, Julian L. Leibowitz -1

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7. The Bioinformatics Bookshelf: Teach Yourself Computational Biology? Bioinformatics: The Machine Learning Approach By Pierre Baldi and Soren Brunak Cambridge, MA: MIT Press (1998). 351 pp. $40.00; Bioinformatics: A Practical Guide to the Analysis of Genes and Proteins Edited by Andreas D. Baxevanis and B. F. Francis Ouellette New York: Wiley-lnterscience (1998). 370 pp. $59.95; Guide to Human Genome Computing, Second Edition Edited by Martin J. Bishop San Diego, CA: Academic Press (1998). 306 pp. $69.95; Biological Sequence Analysis: Probabilistic Models of Proteins and Nucleic Acids By Richard Durbin, Sean Eddy, Anders Krogh, and Graeme Mitchison Cambridge: Cambridge University Press (1998). 356 pp. $34.95; Algorithms on Strings, Trees, and Sequences: Computer Science and Computational Biology By Dan Gusfield Cambridge: Cambridge University Press (1997). 534 pp. $59.95; Introduction to Computational Molecular Biology By Joao Setubal and Joao Meidanis Boston: PWS Publishing (1997). 296 pp. $61.95 [O] . Pickeral Oxana K, Boguski Mark S 1999

机译：生物信息学书架：自学计算生物学吗？生物信息学：机器学习方法，作者：Pierre Baldi和Soren Brunak剑桥，麻省：麻省理工学院出版社（1998）。 351页，$ 40.00；生物信息学：由Andreas D. Baxevanis和B. F. Francis Ouellette编辑的基因和蛋白质分析实用指南纽约：Wiley-Interscience（1998）。 370页，$ 59.95；《人类基因组计算指南》，第二版，由马丁·J·毕晓普（Martin J. Bishop）编辑，加利福尼亚州圣地亚哥：学术出版社（1998）。 306页，$ 69.95；生物序列分析：蛋白质和核酸的概率模型Richard Durbin，Sean Eddy，Anders Krogh和Graeme Mitchison剑桥：剑桥大学出版社（1998年）。 356页，$ 34.95；字符串，树和序列上的算法：计算机科学和计算生物学Dan Danssfield剑桥：剑桥大学出版社（1997年）。 534页，$ 59.95； Joao Setubal和Joao Meidanis Boston撰写的《计算分子生物学概论》：PWS出版（1997）。 296羽61.95美元

Bioinformatic Approach to Inter Functional Interactions within Protein Sequences

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