Cell-permeable Circadian Clock Proteins

机译：细胞渗透性昼夜节律钟蛋白

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Humans and most other organisms manifest circadian (daily) rhythms that are controlled by an endogenous biochemical oscillator. These 'biological clocks' are important to human physiology. For example, psychiatric and medical studies have shown that circadian rhythmicity is involved in some forms of depressive illness, 'jet lag', drug tolerance/efficacy, memory, and insomnia. Therefore, understanding the biochemical mechanism of circadian clocks may lead to procedures which will be useful in the diagnosis and treatment of disorders that are relevant to sleep, mental health, and pharmacology. Although recent breakthroughs in the field of circadian rhythms have identified a number of proteins that appear to act as clock components, we have only just begun to understand how these components interact functionally with themselves and the environment to generate a highly precise 24 hour oscillation that is temperature compensated and entrained to the daily cycle. We will test hypotheses concerning the significance of rhythmic clock protein abundance by using new methods to introduce proteins directly into cells by peptide-mediated transduction across cell membranes. These studies will yield results of theoretical importance, but also have the potential for designing treatments for jet lag, insomnia, and other clock-related disorders.

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作者
Johnson, C. H.;
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年度 2002
页码 1-3
总页数 3
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Circadian rhythms; Proteins; Biological rhythms; Peptides; Biochemistry; Stress(Physiology); Diagnosis(Medicine); Cells(Biology); Drug tolerance; Jet lag; Insomnia;

机译：昼夜节律;蛋白质;生物节律;肽;生物化学;应激（生理学）;诊断（医学）;细胞（生物学）;药物耐受性;时差;失眠;

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1. Regulation of behavioral circadian rhythms and clock protein PER1 by the deubiquitinating enzyme USP2 Regulation of behavioral circadian rhythms and clock protein PER1 by the deubiquitinating enzyme USP2 Regulation of behavioral circadian rhythms and clock protein PER1 by the deubiquitinating enzyme USP2 [J] . Yaoming Yang, Chan Hyun Na, Nathalie Bédard, Biology Open . 2012,第8期

机译：去泛素化酶USP2对行为昼夜节律和时钟蛋白PER1的调控作用去泛素化酶USP2对行为昼夜节律和时钟蛋白PER1的调控作用
2. Immunoreactivities to three circadian clock proteins in two ground crickets suggest interspecific diversity of the circadian clock structure [J] . Shao QM, Sehadova H, Ichihara N, Journal of biological rhythms . 2006,第2期

机译：在两个地面中对三种生物钟蛋白的免疫反应性表明生物钟结构的种间多样性
3. How is the inner circadian clock controlled by interactive clock proteins? Structural analysis of clock proteins elucidates their physiological role [J] . Merbitz-Zahradnik Torsten, Wolf Eva FEBS letters. . 2015,第14期

机译：内部生物钟如何由交互式时钟蛋白控制？时钟蛋白的结构分析阐明了它们的生理作用
4. MS-Based Approaches to Define Protein Interactions in Dynamic Systems: Application to Bacterial Circadian Clocks [C] . Rebecca J. Rose, Joost Snijder, Christian Brettschneider, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2011

机译：基于MS的方法来定义动态系统中蛋白质相互作用：对细菌昼夜节律的应用
5. JmjC Proteins in the Circadian Clock and Energy Metabolism [D] . Saran, Anand R. 2019

机译：JMJC蛋白在昼夜时钟和能量新陈代谢
6. The Mammalian Circadian Clock Protein Period Counteracts Cryptochrome in Phosphorylation Dynamics of Circadian Locomotor Output Cycles Kaput (CLOCK) [O] . Ritsuko Matsumura, Yoshiki Tsuchiya, Isao Tokuda, 2014

机译：哺乳动物昼夜节律时钟蛋白周期抵消昼夜运动输出周期Kaput（CLOCK）磷酸化动力学中的隐铬。
7. How is the inner circadian clock controlled by interactive clock proteins? Structural analysis of clock proteins elucidates their physiological role [O] . Merbitz-Zahradnik Torsten, Wolf Eva 2015

机译：内部生物钟如何由相互作用的时钟蛋白控制？时钟蛋白的结构分析阐明了它们的生理作用

Cell-permeable Circadian Clock Proteins

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