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首页> 美国政府科技报告 >Radiolabeled androgens and progestins as imaging agents for tumors of the prostate and breast. Progress report
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Radiolabeled androgens and progestins as imaging agents for tumors of the prostate and breast. Progress report

机译：放射性标记的雄激素和孕激素作为前列腺和乳腺肿瘤的成像剂。进度报告

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The specific aims of the previous grant application can be summarized as follows: Synthesize fluorine-substituted progestins from the following high affinity classes: R5020 (promegestone), norgestrel, RU486, and retroprogestins; Synthesize fluorine-substituted androgens from the following high affinity classes: mibolerone, R1881 (metribolone) and 2-oxometribolone; Evaluate the receptor binding and non-specific binding of these fluorosteroids by in vitro binding assays; Develop and optimize fluoride ion substitution reactions suitable for the rapid, efficient and convenient preparation of these fluorosteroids in high specific activity, F-18 labeled form; and Evaluate the target tissue uptake of the F-18 labeled androgens and progestins in experimental animals.

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