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Molecular Targets, DNA Breakage, DNA Repair: Their Roles in Mutation Induction in Mammalian Germ Cells.

机译：分子靶，DNa断裂，DNa修复：它们在哺乳动物生殖细胞突变诱导中的作用。

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Variability in genetic sensitivity among different germ-cell stages in the mammal to various mutagens could be the result of how much chemical reaches the different stages, what molecular targets may be affected in the different stages and whether or not repair of lesions occurs. Several chemicals have been found to bind very strongly to protamine in late-spermatid and early-spermatozoa stages in the mouse. The chemicals also produce their greatest genetic damage in these same germ-cell stages. While chemical binding to DNA has not been correlated with the level of induced genetic damage, DNA breakage in the sensitive stages has been shown to increase. This DNA breakage is believed to indirectly result from chemical binding to sulfhydryl groups in protamine which prevents normal chromatin condensation within the sperm nucleus. 22 refs., 5 figs.

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作者
Sega, G. A.;
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作者单位

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年度 1989
页码 1-23
总页数 23
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Germ Cells; Strand Breaks; Animal Growth; Dose-Response Relationships; Genetic Effects; Malformations; Mice; Mutagen Screening; DNA repair; Mutations; ERDA/550301; DNA damage;

机译：生殖细胞;链断裂;动物生长;剂量 - 反应关系;遗传效应;畸形;小鼠;诱变筛选; DNa修复;突变; ERDa / 550301; DNa损伤;

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专利

1. DNA replication and transcription direct a DNA strand bias in the process of targeted gene repair in mammalian cells. [J] . Brachman EE, Kmiec EB Journal of Cell Science . 2004,第Pta17期

机译：DNA复制和转录指导哺乳动物细胞中靶向基因修复过程中的DNA链偏向。
2. DNA repair mechanisms in mammalian germ cells. [J] . Ozturk S, Demir N Histology and histopathology . 2011,第4a6期

机译：哺乳动物生殖细胞中的DNA修复机制。
3. DNA repair and replication influence the number of mutations per adduct of polycyclic aromatic hydrocarbons in mammalian cells. [J] . Lagerqvist A, Hakansson D, Lundin C, DNA repair . 2011,第8期

机译：DNA修复和复制影响哺乳动物细胞中多环芳烃每加合物的突变数。
4. Detecting Rare Mutations in Cell-Free DNA by Integrating an Ultrafast Amplicon-Based Targeted Library Preparation Method with Double-Stranded Unique Molecular Identifiers [C] . Yang Lily Liu International Molecular Medicine Tri-Conference. . 2019

机译：通过与双链独特的分子标识符集成超速率扩增子靶向文库制备方法，通过与双链独特的分子标识符进行整合来检测无细胞DNA的罕见突变
5. The Essential Roles of DNA Resection and The Impact of Loss of Function NHEJ Mutations on DSB Repair In Human Somatic Cells. [D] . Lee, Eu Han. 2014

机译：DNA切除的基本作用以及NHEJ功能缺失对人体细胞DSB修复的影响。
6. Targeted DNA methylation by homology-directed repair in mammalian cells. Transcription reshapes methylation on the repaired gene [O] . Annalisa Morano, Tiziana Angrisano, Giusi Russo, 2014

机译：在哺乳动物细胞中通过同源性定向修复进行靶向DNA甲基化。转录重塑修复基因的甲基化
7. Bacterial DNA repair genes and their eukaryotic homologues: 4. The role of nucleotide excision DNA repair (NER) system in mammalian cells. [O] . Leena Maddukuri, Dominika Dudzińska, Barbara Tudek 2007

机译：细菌DNA修复基因及其真核同源物：4。核苷酸切除DNA修复（NER）系统在哺乳动物细胞中的作用。
8. Molecular Targets, DNA Breakage, DNA Repair: Their Roles in Mutation Induction in Mammalian Germ Cells [R] . Sega, G. A. 1989

机译：分子靶，DNa断裂，DNa修复：它们在哺乳动物生殖细胞突变诱导中的作用

Molecular Targets, DNA Breakage, DNA Repair: Their Roles in Mutation Induction in Mammalian Germ Cells.

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