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High-LET Dose-Response Characteristics by Track Structure Theory of Heavy Charged Particles

机译：重载荷粒子轨道结构理论的高LET剂量响应特性

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The track structure theory developed by Katz and co-workers ascribes the effect of high-LET radiation to the highly inhomogeneous dose distribution due to low energy delta -rays ejected from the particle track. The theory predicts the effectiveness of high-LET radiation by using the ion parameters zsub(eff') effective charge of the ion, and beta = v/c, the relative ion velocity, together with the characteristic dose D sub 37 derived from low-LET dose-response characteristic of the detector and the approximate size asub(0) of the sensitive element of the detector. exp 60 Co gamma-irradiation is used as a reference low-LET radiation, while high-LET radiation ranging from 16 MeV protons to 4 MeV/amu exp 16 0-ions covering an initial LET range of 30-5500 MeVcm exp 2 /g is obtained from a tandem Van de Graaff accelerator. A thin film (5mg/cm exp 2 ) radiochromic dye cyanide plastic dosemeter was used as detector with the characteristic dose of 16.8 Mrad and a sensitive element size of 10 exp -7 cm. Theoretical and experimental effectiveness, RBE, agreed within 10 to 25% depending on LET. (Atomindex citation 12:642394)

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