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Cell-Directed Assembly of an Integrated Nanoelectronic/Nanophotonic Device for Probing Cellular Responses on the Nanoscale

机译：用于探测纳米级细胞反应的集成纳米电子/纳米光子器件的细胞定向组装

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Our discovery that the introduction of living cells (Saccharomyces cerevisiae) alters dramatically the evaporation driven self-assembly of lipid-silica nanostructures suggested the formation of novel bio/nano interfaces useful for cellular interrogation at the nanoscale. This one year 'out of the box' LDRD focused on the localization of metallic and semi-conducting nanocrystals at the fluid, lipid-rich interface between S. cerevisiae and the surrounding phospholipid-templated silica nanostructure with the primary goal of creating Surface Enhanced Raman Spectroscopy (SERS)-active nanostructures and platforms for cellular integration into electrode arrays. Such structures are of interest for probing cellular responses to the onset of disease, understanding of cell-cell communication, and the development of cell-based bio-sensors. As SERS is known to be sensitive to the size and shape of metallic (principally gold and silver) nanocrystals, various sizes and shapes of nanocrystals were synthesized, functionalized and localized at the cellular surface by our 'cell-directed assembly' approach. Laser scanning confocal microscopy, SEM, and in situ grazing incidence small angle x-ray scattering (GISAXS) experiments were performed to study metallic nanocrystal localization.

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Carnes, E. C.; Ashely, C. E.; Caca, H. K.; Lopez, D. M.; Dunphy, D. R.; Burckel, D. B.; Singh, S.; Tallant, D. R.; Simposn, R. L.; Fan, H.;
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年度 2006
页码 1-32
总页数 32
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Nanostructures ; Cell constituents ; Probes ; Fabrication ; Response functions ; Monitoring ; Phospholipids ; Raman spectroscopy ; Silica ; Saccharomyces;

机译：纳米结构;细胞成分;探针;制造;响应函数;监测;磷脂;拉曼光谱;二氧化硅;酿酒酵母;

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专利

1. Hierarchical Three-Dimensional Layer-by-Layer Assembly of Carbon Nanotube Wafers for Integrated Nanoelectronic Devices [J] . Takeo Yamada, Natsumi Makiomoto, Atsuko Sekiguchi, Nano letters . 2012,第9期

机译：集成纳米电子器件用碳纳米管晶片的三维三维分层组装
2. Integrated thermal probe for SThM investigation of micro- and nanoelectronic devices [J] . PAWEL JANUS, rnDARIUSZ SZMIGIEL, rnGRZEGORZ WIELGOSZEWSKI, Elektronika . 2010,第6期

机译：集成式热探针，用于对微纳电子器件进行SThM研究
3. One-Dimensional Nanostructures of π-Conjugated Molecular Systems: Assembly, Properties, and Applications from Photovoltaics, Sensors, and Nanophotonics to Nanoelectronics [J] . Felix Sunjoo Kim, Guoqiang Ren, Samson A. Jenekhe Chemistry of Materials: A Publication of the American Chemistry Society . 2011,第3期

机译：π共轭分子系统的一维纳米结构：组装，性质和从光伏，传感器和纳米光子学到纳米电子学的应用
4. Nanostructuring Based on Scanning Probe Microscopy and Bottom Up Assembly for Future Nanoelectronic Devices [C] . International Conference on Micro amp; Nano Systems 2002 (ICMNS 2002) Aug 11-14, 2002 Kunming, China . 2002

机译：基于扫描探针显微镜和自底向上组装的纳米结构，用于未来的纳米电子器件
5. Probing Cellular Response to Heterogeneous Rigidity at the Micro- and Nanoscale. [D] . Liao, Jinyu. 2017

机译：在微尺度和纳米尺度上探测对异质刚性的细胞反应。
6. Nanoelectronics Meets Biology: From Novel Nanoscale Devices for Live Cell Recording to 3D Innervated Tissues† [O] . Xiaojie Duan, Charles M. Lieber -1

机译：纳米电子学与生物学相遇：从用于活细胞记录的新型纳米器件到3D受神经支配的组织†
7. Cell-directed assembly on an integrated nanoelectronic/nanophotonic device for probing cellular responses on the nanoscale. [O] . Brinker, C. Jeffrey, Dunphy, Darren Robert, Ashley, Carlee E. (University of New Mexico, Albuquerque, NM), 2006

机译：在集成的纳米电子/纳米光子器件上进行细胞定向组装，用于探测纳米级的细胞反应。

Cell-Directed Assembly of an Integrated Nanoelectronic/Nanophotonic Device for Probing Cellular Responses on the Nanoscale

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