• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国政府科技报告 >Effects of the Benomyl Metabolite, Carbendazim, on the Hypothalamic-Pituitary Reproductive Axis in the Male Rat
【24h】

Effects of the Benomyl Metabolite, Carbendazim, on the Hypothalamic-Pituitary Reproductive Axis in the Male Rat

机译：苯菌灵代谢物多菌灵对雄性大鼠下丘脑 - 垂体生殖轴的影响

获取原文
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Carbendazim (MBC), the bioactive metabolite of the fungicide benomyl, has been reported to induce a number of testicular alterations in male rats. In order to broaden an exploration of its effects on the reproductive system, the present study focused on the possible presence of concurrent endocrine changes in the hypothalamic and pituitary components of the brain-pituitary-testicular axis. Subchronic administration of MBC (50, 100, 200 or 400 mg/kg) was found to cause a dose-related elevation in serum follicle-stimulating hormone (FSH) and pituitary luteinizing hormone (LH). Values for prolactin and thyroid-stimulating hormone remained unchanged. The effect on FSH was associated with fertility status and independent of serum testosterone. It may be linked to alterations in Sertoli cell-pituitary signaling. Changes in pituitary LH at 400 mg/kg were unrelated to fertility and suggest an influence of MBC on LH metabolism. (Copyright (c) 1989 Elsevier Scientific Publishers Ireland Ltd.)

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号