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首页> 美国政府科技报告 >Dermatopharmacokinetics and Pharmacodynamics: In Vivo Analysis of Common Paint Product Solvents, April 2003
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Dermatopharmacokinetics and Pharmacodynamics: In Vivo Analysis of Common Paint Product Solvents, April 2003

机译：皮肤药代动力学和药效学：常见油漆产品溶剂的体内分析，2003年4月

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Exposure assessment is an important component in estimating health risk for individuals exposed to chemicals. Regulatory agencies have established standards for allowable occupational exposures, primarily via the inhalation pathway. In contrast, very little data is available to provide agencies sufficient guidance to establish permissible dermal exposure levels. Part of this shortfall lies in the fact that measurement of the amount of chemical absorbed through the skin is both experimentally difficult and time-consuming. In the research described here an innovative methodology was utilized to non-invasively evaluate dermal absorption by continually analyzing exhaled breath. Because breath concentrations can be used to reflect blood concentrations, constant analysis of exhaled breath provides an opportunity to evaluate differences in the rapidly changing blood compartment that occurs immediately following peak exposure. Animal studies were conducted to collect time-course data on the dermal absorption of two common solvents toluene and methyl ethyl ketone. Both of these solvents are components of various paint and adhesive products, and may be frequently encountered in the occupational setting and by the consumer. Studies were conducted to expose animals to these compounds to provide an understanding of the impact of exposure matrix on dermal absorption. The exhaled breath kinetic data collected from each exposed animal was subsequently evaluated using an established mathematical model to determine the rate of dermal absorption.

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