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Assessment of Thyroid Follicular Cell Tumors

机译:甲状腺滤泡细胞肿瘤的评估

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The Report presents science policy guidance that describes the procedures theAgency will use in the evaluation of potential human cancer hazard and dose-response assessments from chemicals that are animal thyroid carcinogens. The Forum Report describes when, under clearly specified conditions, chemical carcinogenesis in thyroid follicular cells can be analyzed as a nonlinear phenomenon, rather than assuming low dose linearity as EPA customarily does for carcinogenic compounds. Four hypothetical cases are summarized which illustrate how to evaluate toxicological data and make hazard and dose-response estimation choices. The procedures and considerations developed in the Forum Report embody currenty scientific knowledge of thyroid carcinogenesis and evolving science policy.

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