首页> 美国政府科技报告 >Sensitivity to 3,3'-Iminodipropionitrile Differs for High- and MidfrequencyHearing Loss in the Developing Rat

【24h】

Sensitivity to 3,3'-Iminodipropionitrile Differs for High- and MidfrequencyHearing Loss in the Developing Rat

机译：对3,3'-氨基二丙腈的敏感性不同于发育期大鼠的高频和中频耳损失

获取原文

页面导航

摘要
著录项
相似文献
相关主题

摘要

3,3'-Iminodipropionitrile (IDPN) has been demonstrated to produce a loss ofhearing following both neonatal and adult exposures. Adult exposure induces a full spectrum hearing loss, whereas early postnatal exposure produces a high-frequency loss only. The purpose of this work was to delineate the period of development during which the rat becomes sensitive to the full ototoxic effects of IDPN. Primiparous Long Evans rats or their offspring were exposed to either saline or 300 mg/kg IDPN for three consecutive days. Ages of exposure were as follows: gestational days 15-17 or postnatal days (PND) 1-3, 5-7, 15-17, 20-22, 25-27, 30-32, 40-42, or 70-72. All animals were tested as adults for auditory

著录项

作者
Goldey, E. S.; Kehn, L. S.; Crofton, K. M.;
展开▼
作者单位

展开▼
年度 1993
页码 1-10
总页数 10
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Toxicity; Development; High-frequency hearing loss; Hearing disorders; Rats; Audiometry; Fetal death; Prenatal exposure delayed effects; Reprints;

机译：毒性;发育;高频听力损失;听力障碍;大鼠;听力测定;胎儿死亡;产前暴露延迟效应;重印;

相似文献

外文文献
中文文献
专利

1. Relationship between insult intensity and mode of hair cell loss in the vestibular system of rats exposed to 3,3'-iminodipropionitrile. [J] . Seoane A, Dememes D, Llorens J The Journal of Comparative Neurology . 2001,第4期

机译：暴露于3,3'-亚氨基二丙腈的大鼠前庭系统中侵袭强度与毛细胞丢失方式的关系。
2. Distal effects in a model of proximal axonopathy: 3,3'-iminodipropionitrile causes specific loss of neurofilaments in rat vestibular afferent endings [J] . Ana Seoane, Danielle Demêmes, Jordi Llorens Acta Neuropathologica . 2003,第5期

机译：在近端轴突病模型中的远距离影响：3,3'-亚氨基二丙腈导致大鼠前庭传入神经末梢神经丝的特异性丧失
3. Alteration of microRNA expressions in the pons and medulla in rats after 3,3′-iminodipropionitrile administration [J] . Keiko Ogata, Masahiko Kushida, Kaori Miyata, Journal of Toxicologic Pathology . 2016,第4期

机译：3,3'-亚氨基二丙腈施用后大鼠脑桥和延髓中microRNA表达的变化
4. Preparation and Characterization of Electrospun Poly (3,3'5,5'-tetramethyl-4,4'-diaminodiphenyl-butyltoluene-co-3,3',4,4'-biphenyltetracarboxylicdianhydride) Nanofiber Membranes [C] . PENG Yi, JIN Junhong, YANG Shenglin, International Conference on Manufacturing Science and Engineering . 2012

机译：电纺聚（3,3'5,5'-四甲基-4,4'-二氨基二苯基 - 丁甲苯-CO-3,3'，4,4'-二苯基羧基二酐）纳米纤维膜的制备及表征
5. The effects of hearing loss on the importance of high- and low-frequency information to speech understanding. [D] . Hornsby, Benjamin Wade Young. 2002

机译：听力损失对高频和低频信息对语音理解的重要性的影响。
6. Job Loss or Income Loss: How the Detrimental Effect of Unemployment on Mens Life Satisfaction Differs by Immigration Status [O] . Jing Shen, Irena Kogan 2020

机译：失业或收入损失：失业对男人生活满意度的不利影响因移民身份而不同
7. Alteration of microRNA expressions in the pons and medulla in rats after 3,3′-iminodipropionitrile administration [O] . Keiko Ogata, Masahiko Kushida, Kaori Miyata, 2016

机译：在3,3'-伊宁替洛哌亚替代给药后大鼠PONS和Medulla中微小瘤表达的改变
8. Effects of 3,3'-Iminodipropionitrile on Acquisition and Performance of SpatialTasks in Rats [R] . Llorens, J., Crofton, K. M., Peele, D. B. 1994

机译：3,3'-氨基二丙腈对大鼠空间特征的获得和表现的影响

Sensitivity to 3,3'-Iminodipropionitrile Differs for High- and MidfrequencyHearing Loss in the Developing Rat

摘要

著录项

相似文献

相关主题

期刊订阅