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Characterization of Flow Dynamics in Vessels with Complex Geometry using Doppler Optical Coherence Tomography

机译：多普勒光学相干断层扫描技术表征复杂几何形状的容器中的流动动力学

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摘要

The study of flow dynamics in complex geometry vessels is highly important in manybiomedical applications where the knowledge of the mechanic interactions between themoving fluid and the housing media plays a key role for the determination of theparameters of interest, including the effect of blood flow on the possible rupture ofatherosclerotic plaques. Doppler Optical Coherence Tomography (DOCT) is an optic,non-contact, non-invasive technique able to achieve detailed analysis of the flow/vesselinteractions, allowing simultaneously high resolution imaging of the morphology andcomposition of the vessel and of the flow velocity distribution along the measuredcross-section. DOCT system was developed to image high-resolution one-dimensionaland multi-dimensional velocity distribution profiles of Newtonian and non-Newtonianfluids flowing in vessels with complex geometry, including Y-shaped and T-shapedvessels, vessels with aneurism, bifurcated vessels with deployed stent and scaffolds.The phantoms were built to study the interaction of the flow dynamics with differentchannel geometries and to map the related velocity profiles at several inlet volume flowrates. Feasibility studies for quantitative observation of the turbulence of flows arisingwithin the complex geometry vessels are discussed. In addition, optical clearing of skintissues has been utilized to achieve DOCT imaging of human blood vessels in vivo, at adepth up to 1.7 mm. Two-dimensional OCT images of complex flow velocity profiles inblood vessel phantom and in vivo subcutaneous human skin tissues are presented. Theeffect of optical clearing on in vivo images is demonstrated and discussed. DOCT wasalso applied for imaging scaffold structures and for mapping flow distributions withinthe scaffold.
机译：在许多生物医学应用中，对复杂几何形状的容器中的流动动力学的研究非常重要，在这些应用中，运动流体与外壳介质之间的机械相互作用的知识对于确定感兴趣的参数（包括血流对可能的影响）的决定起着关键作用。动脉粥样硬化斑块破裂。多普勒光学相干断层扫描（DOCT）是一种光学，非接触式，无创技术，能够对流量/血管相互作用进行详细分析，从而可以同时对血管的形态和组成以及沿血管的流速分布进行高分辨率成像。测量横截面。开发了DOCT系统以对在复杂几何形状的血管中流动的牛顿和非牛顿流体的高分辨率一维和多维速度分布图进行成像，这些血管包括Y形和T形血管，动脉瘤血管，带支架的分叉血管以及建立体模是为了研究流动动力学与不同通道几何形状之间的相互作用，并绘制一些入口体积流量下的相关速度分布图。讨论了定量观察复杂几何形状容器内流动湍流的可行性研究。另外，皮肤组织的光学清除已被用于实现人血管在体内的DOCT成像，深度达1.7mm。呈现了血管幻影和体内皮下人皮肤组织中复杂流速分布的二维OCT图像。证明并讨论了光学清除对体内图像的影响。 DOCT还被用于对支架结构进行成像并用于绘制支架内的流量分布。

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    Bonesi Marco;

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  • 年度 2008
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  • 正文语种 {"code":"en","name":"English","id":9}
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