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SARS-CoV-2 Infections in the World: An Estimation of the Infected Population and a Measure of How Higher Detection Rates Save Lives

机译:SARS-COV-2在世界上感染:对受感染的人口的估计和衡量检测利率如何拯救生命

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摘要

This paper provides an estimation of the accumulated detection rates and the accumulated number of infected individuals by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Worldwide, on July 20, it has been estimated above 160 million individuals infected by SARS-CoV-2. Moreover, it is found that only about 1 out of 11 infected individuals are detected. In an information context in which population-based seroepidemiological studies are not frequently available, this study shows a parsimonious alternative to provide estimates of the number of SARS-CoV-2 infected individuals. By comparing our estimates with those provided by the population-based seroepidemiological ENE-COVID study in Spain, we confirm the utility of our approach. Then, using a cross-country regression, we investigated if differences in detection rates are associated with differences in the cumulative number of deaths. The hypothesis investigated in this study is that higher levels of detection of SARS-CoV-2 infections can reduce the risk exposure of the susceptible population with a relatively higher risk of death. Our results show that, on average, detecting 5 instead of 35 percent of the infections is associated with multiplying the number of deaths by a factor of about 6. Using this result, we estimated that 120 days after the pandemic outbreak, if the US would have tested with the same intensity as South Korea, about 85,000 out of their 126,000 reported deaths could have been avoided.
机译:本文通过新型严重急性呼吸综合征冠状病毒2(SARS-COV-2)估计累积的检测率和受感染的个体累积数量的估计。全球,7月20日,估计超过160万人被SARS-COV-2感染的人。此外,发现仅检测11个感染个体中的约1个。在不经常可用的基于人口的血液化学研究的信息背景下,本研究表明了一种解析的替代方案,提供了SARS-COV-2受感染的个体数量的估计。通过将我们的估计与西班牙的基于人口的血清术eNE-covid研究提供的估计进行比较,我们确认了我们的方法的效用。然后,使用越野回归,我们调查了检测率的差异与累积死亡人数的差异有关。在本研究中研究的假设是较高水平的SARS-COV-2感染程度可以降低易感人群的风险暴露,具有相对较高的死亡风险。我们的结果表明,平均检测5代替35%的感染与将死亡人数乘以约6.使用这一结果,我们估计大流行爆发后120天,如果美国会已经用与韩国相同的强度进行了测试,可能已经避免了大约85,000名报告的死亡人数。

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  • 作者

    Carlos Villalobos;

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  • 年度 2020
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  • 原文格式 PDF
  • 正文语种 eng
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