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首页> 外文OA文献 >The Study of Naphthoquinones and Their Complexes with DNA by Using Raman Spectroscopy and Surface Enhanced Raman Spectroscopy: New Insight into Interactions of DNA with Plant Secondary Metabolites
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The Study of Naphthoquinones and Their Complexes with DNA by Using Raman Spectroscopy and Surface Enhanced Raman Spectroscopy: New Insight into Interactions of DNA with Plant Secondary Metabolites

机译：通过使用拉曼光谱和表面增强拉曼光谱法研究萘醌及其与DNA的复合物：新的洞察DNA与植物次级代谢物相互作用

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Naphthoquinones represent the group of plant secondary metabolites with cytotoxic properties based on their ability to generate reactive oxygen species and interfere with the processes of cell respiration. Due to this fact, the possible cytotoxic mechanisms on cellular and subcellular levels are investigated intensively. There are many targets of cytotoxic action on the cellular level; however, DNA is a critical target of many cytotoxic compounds. Due to the cytotoxic properties of naphthoquinones, it is necessary to study the processes of naphthoquinones, DNA interactions (1,4-naphthoquinone, binapthoquinone, juglone, lawsone, plumbagin), especially by using modern analytical techniques. In our work, the Raman spectroscopy was used to determine the possible binding sites of the naphthoquinones on the DNA and to characterize the bond of naphthoquinone to DNA. Experimental data reveals the relationships between the perturbations of structure-sensitive Raman bands and the types of the naphthoquinones involved. The modification of DNA by the studied naphthoquinones leads to the nonspecific interaction, which causes the transition of B-DNA into A-DNA conformation. The change of the B-conformation of DNA for all measured DNA modified by naphthoquinones except plumbagin is obvious.
机译：萘醌表示基团植物次生代谢物的基于其来生成活性氧，并用细胞呼吸的处理能力干扰细胞毒性性质。由于这一事实，在细胞和亚细胞水平的可能细胞毒作用机制的深入研究。有细胞水平上的细胞毒性作用的许多目标;然而，DNA是许多细胞毒性化合物的一个关键目标。由于萘醌的细胞毒性特性，有必要特别是通过使用现代分析技术来研究萘醌，DNA相互作用（1,4-萘醌，binapthoquinone，胡桃醌，醌，白花丹素），的处理。在我们的工作中，拉曼光谱来确定DNA上的萘可能的结合位点和萘醌的结合特征的DNA。实验数据表明结构敏感的拉曼频带的扰动和类型所涉及的萘醌之间的关系。 DNA的由所研究的萘醌通向非特异性相互作用，从而导致B-DNA导入A-DNA构象转变的变形例。 DNA的B-构象的由萘醌改性除了白花丹素所有测量DNA的变化是显而易见的。

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