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Transcriptomic data indicating differential expressed genes between HIV-1 Associated Nephropathy (HIVAN) mouse model (Tg26) and wildtype mice

机译:表明HIV-1相关肾病(HIVAN)小鼠模型(TG26)和野生型小鼠之间的差异表达基因的转录组数据

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摘要

Tg26 mice are robust models of human immunodeficiency virus 1 associated nephropathy (HIVAN). These mice are useful for HIVAN pathology analysis, and recent studies suggest that the Tg26 mouse model is an excellent model of other chronic kidney diseases. We performed RNA seq analysis of differential gene expression in the kidneys of Tg26 mice. Kidneys were collected from Tg26 mice and wildtype (WT) littermates at 3 months of age. The raw data were analyzed for differential gene expression using a negative binomial generalized linear model in the DeSeq2 software package. We used P-Value ≤0.05 and an absolute fold change of 1.5 to identify top 50 upregulated and top 50 downregulated differentially expressed genes between the WT and Tg26 mice. As expected inflammatory genes were among the top differentially regulated genes. Our data provides yet another level of information to help gain a more comprehensive understanding of disease progression and identify potential drug targets for HIVAN and chronic kidney diseases.
机译:TG26小鼠是人类免疫缺陷病毒1相关肾病(HIVAN)的鲁棒模型。这些小鼠可用于HiVAN病理分析,最近的研究表明TG26小鼠模型是其他慢性肾病的优秀模型。我们在TG26小鼠肾脏中进行了差异基因表达的RNA SEQ分析。在3个月的时候从TG26小鼠和野生型(WT)中收集肾脏收集。分析了使用DESQ2软件包中的负二项式广义线性模型进行差分基因表达的原始数据。我们使用p值≤0.05,绝对折叠变化为1.5,以识别WT和TG26小鼠之间的前50个上调和前50个下调的差异表达基因。随着预期的炎症基因在顶部差异调节的基因中。我们的数据提供了另一级信息,以帮助获得对疾病进展的更全面的了解,并确定潜在的幼儿园和慢性肾病的潜在药物靶标。

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