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Structure-Based Design of 5Methylpyrimidopyridone Derivatives as New Wild-Type Sparing Inhibitors of the Epidermal Growth Factor Receptor Triple Mutant (EGFRL858R/T790M/C797S)

机译：5甲基吡啶吡啶酮衍生物的基于结构的设计作为表皮生长因子受体三重突变体的新型野生型腐败抑制剂（EGFR1858R / T790M / C797S）

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1. Structure-Based Design of 5-Methylpyrimidopyridone Derivatives as New Wild-Type Sparing Inhibitors of the Epidermal Growth Factor Receptor Triple Mutant (EGFR(L858R/T790M/C797S)) [J] . Shen Jiayi, Zhang Tao, Zhu Su-Jie, Journal of Medicinal Chemistry . 2019,第15期

机译：5-甲基吡啶吡啶酮衍生物的基于结构的设计，作为表皮生长因子受体三重突变体的新型野生型备用抑制剂（EGFR（L858R / T790M / C797S））
2. Design, Synthesis and Biological Evaluation of the Quinazoline Derivatives as L858R/T790M/C797S Triple Mutant Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors [J] . Mingguang Zhang, Yunyun Wang, Jia Wang, Chemical and Pharmaceutical Bulletin . 2020,第10期

机译：喹唑啉衍生物的设计，合成和生物学评价为L858R / T790M / C797S三重突变表皮生长因子受体酪氨酸激酶抑制剂
3. Design, Synthesis and Biological Evaluation of the Quinazoline Derivatives as L858R/T790M/C797S Triple Mutant Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors [J] . Zhang Mingguang, Wang Yunyun, Wang Jia, Chemical and Pharmaceutical Bulletin . 2020,第10期

机译：喹唑啉衍生物的设计，合成和生物学评价为L858R / T790M / C797S三重突变表皮生长因子受体酪氨酸激酶抑制剂
4. QSAR Study of Quinazoline Derivatives as Inhibitor of Epidermal Growth Factor Receptor-Tyrosine Kinase (EGFR-TK) [C] . La Ode Aman, Widisusanti Abdulkadir, Julitha Geybie Rembet, International Conference on Computation for Science and Technology . 2015

机译：喹唑啉衍生物作为表皮生长因子受体 - 酪氨酸激酶（EGFR-TK）抑制剂的QSAR研究
5. Structure-based design of mutant proteins: I. Molecular docking studies of amino acid binding to wild-type aminoacyl-tRNA synthetases. II. Structure-based design of mutant aminoacyl-tRNA synthetases for non-natural amino acid incorporation. [D] . Zhang, Deqiang. 2003

机译：基于结构的突变蛋白设计：I.氨基酸与野生型氨酰基tRNA合成酶结合的分子对接研究。二。非天然氨基酸掺入的突变型氨酰基-tRNA合成酶的基于结构的设计。
6. Lamellarin 14 a derivative of marine alkaloids inhibits the T790M/C797S mutant epidermal growth factor receptor [O] . Naoyuki Nishiya, Yusuke Oku, Chie Ishikawa, 2021

机译：Ladellarin 14是海洋生物碱的衍生物抑制T790M / C797S突变体表皮生长因子受体
7. How Different Substitution Positions of F, Cl Atoms in Benzene Ring of 5-Methylpyrimidine Pyridine Derivatives Affect the Inhibition Ability of EGFRL858R/T790M/C797S Inhibitors: A Molecular Dynamics Simulation Study [O] . Jingwen E, Ye Liu, Shanshan Guan, 2020

机译：5-甲基嘧啶吡啶衍生物的苯环中F的替代位置不同的替代位置，影响EGFR1858R / T790M / C797S抑制剂的抑制能力：分子动力学模拟研究

Structure-Based Design of 5Methylpyrimidopyridone Derivatives as New Wild-Type Sparing Inhibitors of the Epidermal Growth Factor Receptor Triple Mutant (EGFRL858R/T790M/C797S)

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