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Central hemodynamic parameters to predict cardiovascular outcomes and mortality among the elderly: protocol for a systematic review

机译：中央血流动力学参数预测老年人心血管结果和死亡率：系统审查的议定书

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ABSTRACT BACKGROUND: Central blood pressure is a factor that may predict cardiovascular events. However, its use in clinical practice is not well consolidated. Therefore, the aim of our study will be to summarize the use of central hemodynamic parameters to predict cardiovascular-related outcomes and all-cause mortality. DESIGN AND SETTING: Protocol for systematic review of longitudinal observational studies conducted in healthcare institutions, as presented in the studies included. METHODS: We will perform a systematic search in the electronic databases MEDLINE (via PubMed), EMBASE and LILACS (via Virtual Health Library (VHL)), using health descriptors terms for elderly people and for hemodynamic indices of central blood pressure. We will include articles that evaluated hemodynamic indices and at least one of the following outcomes: all-cause mortality, total cardiovascular death, total non-cardiovascular death, myocardial infarction, stroke, coronary artery restenosis after percutaneous coronary intervention, revascularization and aortic syndromes. Two independent reviewers will conduct analysis on the abstracts selected and on the full-text articles. Two reviewers will independently perform data extraction and evaluate the methodological quality of the articles selected, and a third reviewer will evaluate any divergences. The methodological quality of the studies will be assessed in accordance with the ROBINS-I tool (Risk Of Bias In Non-randomized Studies of Interventions). RESULTS AND CONCLUSIONS: Through this systematic review, we intend to summarize evidence that supports the use of central hemodynamic parameters for central blood pressure to diagnose and perform prognostics on arterial hypertension in elderly patients within clinical practice and predict future cardiovascular events in this population. REGISTRATION: Prospero - CRD42018085264.
机译：摘要背景：中央血压是可能预测心血管事件的因素。然而，它在临床实践中的使用并不是很好的。因此，我们的研究目的是总结中央血液动力学参数的使用，以预测心血管相关的结果和全导致死亡率。设计与环境：在医疗机构中进行的纵向观察研究系统审查的系统审查协议，如在研究中所呈现的。方法：我们将在电子数据库中（通过Pubmed），Embase和Lilacs（虚拟健康库（VHL））进行系统搜索，使用年长人民的健康描述符术语和中枢血压的血液动力学指标。我们将包括评估血液动力学指数的文章和至少一种结果：全因死亡率，总体心血管死亡，总体心血管死亡总额，心肌梗死总量，心肌梗死，冠状动脉再狭窄，经皮冠状动脉干预后，血运重建和主动脉综合征。两个独立审阅者将对所选的摘要和全文文章进行分析。两位审阅者将独立执行数据提取，并评估所选文章的方法质量，第三次审稿人将评估任何分歧。将根据Robins-i工具评估研究的方法论质量（在干预措施的非随机性研究中偏见的风险）。结果与结论：通过该系统审查，我们打算总结支持中央血液动力学参数对中枢血压的使用，以诊断和对临床实践中老年患者的动脉高血压进行诊断，并预测该人群的未来心血管事件。注册：Prospero - CRD42018085264。

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