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首页> 外文期刊>Sao Paulo Medical Journal >Central hemodynamic parameters to predict cardiovascular outcomes and mortality among the elderly: protocol for a systematic review
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Central hemodynamic parameters to predict cardiovascular outcomes and mortality among the elderly: protocol for a systematic review

机译：预测老年人心血管结局和死亡率的主要血液动力学参数：系统评价方案

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ABSTRACT BACKGROUND: Central blood pressure is a factor that may predict cardiovascular events. However, its use in clinical practice is not well consolidated. Therefore, the aim of our study will be to summarize the use of central hemodynamic parameters to predict cardiovascular-related outcomes and all-cause mortality. DESIGN AND SETTING: Protocol for systematic review of longitudinal observational studies conducted in healthcare institutions, as presented in the studies included. METHODS: We will perform a systematic search in the electronic databases MEDLINE (via PubMed), EMBASE and LILACS (via Virtual Health Library (VHL)), using health descriptors terms for elderly people and for hemodynamic indices of central blood pressure. We will include articles that evaluated hemodynamic indices and at least one of the following outcomes: all-cause mortality, total cardiovascular death, total non-cardiovascular death, myocardial infarction, stroke, coronary artery restenosis after percutaneous coronary intervention, revascularization and aortic syndromes. Two independent reviewers will conduct analysis on the abstracts selected and on the full-text articles. Two reviewers will independently perform data extraction and evaluate the methodological quality of the articles selected, and a third reviewer will evaluate any divergences. The methodological quality of the studies will be assessed in accordance with the ROBINS-I tool (Risk Of Bias In Non-randomized Studies of Interventions). RESULTS AND CONCLUSIONS: Through this systematic review, we intend to summarize evidence that supports the use of central hemodynamic parameters for central blood pressure to diagnose and perform prognostics on arterial hypertension in elderly patients within clinical practice and predict future cardiovascular events in this population. REGISTRATION: Prospero - CRD42018085264.
机译：摘要背景：中心血压是可以预测心血管事件的因素。但是，它在临床实践中的使用并没有得到很好的巩固。因此，我们研究的目的是总结使用中央血液动力学参数来预测心血管相关结果和全因死亡率。设计与设置：包括在研究中提出的在医疗机构中进行的纵向观察研究的系统综述的方案。方法：我们将使用老年人的健康描述符术语和中心血压的血液动力学指标，在电子数据库MEDLINE（通过PubMed），EMBASE和LILACS（通过虚拟健康图书馆（VHL））中进行系统搜索。我们将包括评估血液动力学指数和至少以下一项结果的文章：全因死亡率，总心血管死亡，总非心血管死亡，心肌梗塞，中风，经皮冠状动脉介入治疗后冠状动脉再狭窄，血管重建和主动脉综合征。两名独立审稿人将对所选摘要和全文进行分析。两名审稿人将独立执行数据提取并评估所选文章的方法学质量，第三名审稿人将评估任何差异。研究的方法学质量将根据ROBINS-I工具（非随机干预研究中的偏倚风险）进行评估。结果与结论：通过这项系统的综述，我们打算总结一些证据，这些证据支持使用中心血流动力学参数测定中心血压，以在临床实践中诊断和进行老年患者的动脉高压预后，并预测该人群未来的心血管事件。注册：Prospero-CRD42018085264

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