• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文OA文献 >Binge-eating behavior in mice: influences of restriction and palatability in a limited access model
【2h】

Binge-eating behavior in mice: influences of restriction and palatability in a limited access model

机译：小鼠的暴饮暴食行为：在受限访问模型中限制和适口性的影响

页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Animal models of bingeing have typically used stress to induce bingeing. Arecent model, limited-access to high-fat diet (HFD), has shown that caloric restrictionand stress were not required to induce bingeing in rats. This study replicated this modelin mice, explored the fat content within the model, and investigated locomotor activationassociated with binge-eating. Adult mice were maintained on a restricted feeding (RF)schedule of 2 h/d of access to chow or ad lib access to chow, and then provided limitedaccess to 45% HFD or 84% HFD for 30 min 3 d/ week for 6 total snack sessions.Circadian activity was monitored for RF animals offered 84% HFD, and after 6 snacksessions were complete, allowed continuous access to the 45% HFD or the 84% HFD fortwo weeks to explore rebound feeding. Bingeing, defined by increasing intakes acrossdays, was reported for mice offered 45% HFD regardless of deprivation state (RF or adlib), while mice offered 84% HFD only exhibited bingeing when they were restricted.Comparison of male and female mice maintained RF, offered 45% HFD snack, showed that females had higher intake (kcals/g-bw) while ad lib fed mice exhibited no sexdifferences. Circadian recordings for female RF mice offered 84% HFD showed shifts inactivity from the first hour of dark cycle to the hour preceding the snack and supportedthat offering the HFD produced alterations in food-associated arousal. During rebound,female RF mice given 84% HFD showed the highest intakes in week 1, and thenexhibited a marked decline in week 2. The week 1 intake for RF animals were to regainlost body weight and that homeostatic-like intake in week 2 allowed normal body weightmaintenance.Results of this investigation support human data that females are moresusceptible to binge-type eating disorder, shows that limited access to palatable foods forfemales under caloric restriction induces changes in circadian activity, and reveals thatusing mice in this model requires more investigation to optimize binge-behavior. Dietcomparisons also suggest that homeostatic and reward mechanisms may have an additiveeffect on bingeing.
机译：暴饮暴食的动物模型通常使用压力来诱发暴饮暴食。 Arecent模型限制了高脂饮食（HFD）的获取，它表明诱导大鼠暴饮暴食不需要热量限制和压力。这项研究在小鼠中复制了该模型，探索了模型中的脂肪含量，并研究了与暴食有关的运动激活。将成年小鼠维持在限制进食（RF）计划中，即每天吃2小时或随意吃食物，然后在30分钟内每天3d / d限制吃45％HFD或84％HFD，总共6次监测提供84％HFD的RF动物的昼夜活动，完成6次零食后，连续两周连续使用45％HFD或84％HFD探查反弹喂养。据报道，暴饮暴食是通过每天增加摄入量来定义的，无论是否处于剥夺状态（RF或adlib），提供45％HFD的小鼠都处于暴饮暴食状态，而提供84％HFD的小鼠仅在受到限制时才表现出暴饮暴食。 45％的HFD零食表明，雌性的摄入量较高（kcals / g-bw），而随意喂养的小鼠则没有性别差异。雌性RF小鼠的昼夜节律记录提供了84％的HFD，表明从黑暗周期的第一个小时到零食之前的一个小时，无活动状态发生了变化，并支持提供HFD的食物相关唤醒方式的改变。在反弹过程中，HFD含量为84％的雌性RF小鼠在第1周的摄入量最高，然后在第2周表现出明显的下降。RF动物的第1周摄入量是为了减轻体重，第2周，体内稳态的摄入量允许正常这项研究的结果支持了人类数据，即女性更容易暴饮暴食，显示热量限制下女性对可食用食物的有限获取会引起昼夜节律活动的变化，并且表明在此模型中使用小鼠需要更多研究以优化狂欢行为。饮食比较还表明，体内平衡和奖励机制可能对暴饮暴食产生加性效应。

著录项

  • 作者

    Davis Kristina W.;

  • 作者单位
  • 年度 2009
  • 总页数
  • 原文格式 PDF
  • 正文语种 en_US
  • 中图分类
  • 入库时间 2022-08-20 19:41:53

相似文献

  • 外文文献
  • 中文文献
  • 专利

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号