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F-2-Isoprostanes as Novel Biomarkers for Type 2 Diabetes: a Review

机译：F-2-异前列腺素作为2型糖尿病的新型生物标志物：审查。

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Oxidative stress (OS) has been implicated as one of the major underlying mechanisms behind many acute and chronic diseases. However, the measurement of free radicals or their end products is complicated. Isoprostanes, derived from the non-enzymatic peroxidation of arachidonic acid are now considered to be reliable biomarkers of oxidant stress in the human body. Isoprostanes are involved in many of the human diseases such as type 2 diabetes. In type 2 diabetes elevated levels of F-2-Isoprostanes (F-2-IsoPs) have been observed. The measurement of bioactive F-2-IsoPs levels offers a unique noninvasive analytical tool to study the role of free radicals in physiology, oxidative stress-related diseases, and acute or chronic inflammatory conditions. Measurement of oxidative stress by various other methods lacks specificity and sensitivity. This review aims to shed light on the implemention of F-2-IsoPs measurement as a gold-standard biomarker of oxidative stress in type 2 diabetics.
机译：氧化应激（OS）已被认为是许多急性和慢性疾病背后的主要潜在机制之一。但是，自由基或其终产物的测量很复杂。衍生自花生四烯酸的非酶促过氧化的异前列腺素现在被认为是人体中氧化应激的可靠生物标志物。异前列腺素涉及许多人类疾病，例如2型糖尿病。在2型糖尿病中，观察到F-2-异前列腺素（F-2-IsoPs）的水平升高。生物活性F-2-IsoPs水平的测量提供了一种独特的非侵入性分析工具，可以研究自由基在生理学，氧化应激相关疾病以及急性或慢性炎症性疾病中的作用。通过各种其他方法测量氧化应激缺乏特异性和敏感性。这项审查旨在阐明F-2-IsoPs测量作为2型糖尿病患者氧化应激的金标准生物标志物的实施。

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