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首页> 外文OA文献 >Morphometric and DNA Image Analysis of Bronchoalveolar Lavage Fluid Macrophages Nuclei in Interstitial Lung Diseases with Lymphocytic Alveolitis
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Morphometric and DNA Image Analysis of Bronchoalveolar Lavage Fluid Macrophages Nuclei in Interstitial Lung Diseases with Lymphocytic Alveolitis

机译：间质性肺疾病伴淋巴细胞性肺泡炎的支气管肺泡灌洗液巨噬细胞核的形态和DNA图像分析

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Lymphocytic alveolitis is a characteristic of diverse interstitial lung diseases (ILD-s), but macrophages are often more numerous cell population in bronchoalveolar lavage fluid (BALF). Aim of this study is to analyze morphometric characteristics of macrophages nuclei in BALF in patients with ILD-s and to detect possible differences allowing distinguishing sarcoidosis from other lymphocytic alveolitis ILD-s. Thirty-one patient with interstitial lung disease who had lymphocytic alveolitis in BALF cell count (17 sarcoidosis and 14 other ILD-s) and nine controls were included in the study. The following patients data were numbered: age, lymphocyte percentage and CD4/CD8 ratio in BALF. Investigated morphometric parameters of macrophages nuclei were: area, outline, maximal radius, minimal radius, length, breadth, form factor (FF), elongation factor (EF) and DNA image cytometry ploidy status determined with Van Velthoven method. Predicted classifications in classification matrix (forward step-wise method in multivariate discriminant function analysis) based on macrophages nuclei length mean, minimum and maximum, breadth SD, FF mean and lymphocyte % were 100% (9/9) correct for control group, 88.235% (15/17) correct for sarcoidosis, and 92.857% (13/14) correct for other lymphocytic alveolitis ILD group. In total, 92.5% (37/40) of the examinees were correctly classified in particular group upon the observed variables.
机译：淋巴细胞性肺泡炎是多种间质性肺疾病（ILD-s）的特征，但巨噬细胞通常是支气管肺泡灌洗液（BALF）中的大量细胞群体。本研究的目的是分析ILD-s患者BALF中巨噬细胞核的形态特征，并检测可能的差异，从而将结节病与其他淋巴细胞性肺炎ILD-s区分。本研究纳入了31例间质性肺疾病的BALF细胞计数为淋巴细胞性肺泡炎的患者（17结节病和14个其他ILD-s）和9例对照。对以下患者数据进行了编号：BALF中的年龄，淋巴细胞百分比和CD4 / CD8比。研究的巨噬细胞核的形态计量学参数为：面积，轮廓，最大半径，最小半径，长度，宽度，形状因子（FF），延伸因子（EF）和通过Van Velthoven方法确定的DNA图像细胞计数倍性状态。基于巨噬细胞核平均长度，最小和最大，广度SD，FF平均和淋巴细胞％的分类矩阵（多变量判别函数分析中的逐步方法）的预测分类为对照组的88.235，正确率为100％（9/9） ％（15/17）纠正结节病，92.857％（13/14）纠正其他淋巴细胞性肺炎ILD组。总计，根据观察到的变量，将92.5％（37/40）的应试者正确地分为了特定类别。

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