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首页> 外文OA文献 >Fermentation properties and potential prebiotic activity of Bimuno® galacto-oligosaccharide (65 galacto-oligosaccharide content) on in vitro gut microbiota parameters
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Fermentation properties and potential prebiotic activity of Bimuno® galacto-oligosaccharide (65 galacto-oligosaccharide content) on in vitro gut microbiota parameters

机译：Bimuno®低聚半乳糖（65％低聚半乳糖含量）对体外肠道菌群参数的发酵特性和潜在的益生元活性

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Prebiotic oligosaccharides have the ability to generate important changes in the gut microbiota composition that may confer health benefits to the host. Reducing the impurities in prebiotic mixtures could expand their applications in food industries and improve their selectivity and prebiotic effect on the potential beneficial bacteria such as bifidobacteria and lactobacilli. This study aimed to determine the in vitro potential fermentation properties of a 65 % galacto-oligosaccharide (GOS) content Bimuno® GOS (B-GOS) on gut microbiota composition and their metabolites. Fermentation of 65 % B-GOS was compared with 52 % B-GOS in pH- and volume-controlled dose–response anaerobic batch culture experiments. In total, three different doses (1, 0·5 and 0·33 g equivalent to 0·1, 0·05 and 0·033 g/l) were tested. Changes in the gut microbiota during a time course were identified by fluorescence in situ hybridisation, whereas small molecular weight metabolomics profiles and SCFA were determined by 1H-NMR analysis and GC, respectively. The 65 % B-GOS showed positive modulation of the microbiota composition during the first 8 h of fermentation with all doses. Administration of the specific doses of B-GOS induced a significant increase in acetate as the major SCFA synthesised compared with propionate and butyrate concentrations, but there were no significant differences between substrates. The 65 % B-GOS in syrup format seems to have, in all the analysis, an efficient prebiotic effect. However, the applicability of such changes remains to be shown in an in vivo trial.
机译：益生元低聚糖具有在肠道菌群组成中产生重要变化的能力，这些变化可能会给宿主带来健康益处。减少益生元混合物中的杂质可以扩大其在食品工业中的应用，并提高其对潜在有益细菌（如双歧杆菌和乳杆菌）的选择性和益生元作用。这项研究旨在确定65％的低聚半乳糖（GOS）含量的Bimuno®GOS（B-GOS）在肠道菌群组成及其代谢产物上的体外潜在发酵特性。在pH和体积控制的剂量反应厌氧分批培养实验中，将65％B-GOS的发酵与52％B-GOS的发酵进行了比较。总共测试了三种不同的剂量（1、0·5和0·33 g相当于0·1、0·05和0·033 g / l）。通过荧光原位杂交可确定一段时间内肠道菌群的变化，而小分子量代谢组学谱和SCFA分别通过1H-NMR分析和GC确定。在所有剂量的发酵的最初8小时内，65％的B-GOS均显示出微生物群组成的正调节。与丙酸和丁酸的浓度相比，特定剂量的B-GOS的施用引起乙酸盐的显着增加，因为主要的SCFA的合成量高于丙酸和丁酸的浓度，但底物之间没有显着差异。在所有分析中，糖浆形式的65％B-GOS似乎具有有效的益生元作用。但是，这种变化的适用性仍有待体内试验证明。

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