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首页> 外文OA文献 >Melt-extruded polyethylene oxide (PEO) rods as drug delivery vehicles: Formulation, performance as controlled release devices and the influence of co-extruded excipients on drug release profiles
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Melt-extruded polyethylene oxide (PEO) rods as drug delivery vehicles: Formulation, performance as controlled release devices and the influence of co-extruded excipients on drug release profiles

机译：熔融挤出聚环氧乙烷（PEO）棒作为药物输送工具：配方，作为控释装置的性能以及共挤出赋形剂对药物释放曲线的影响

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摘要

The utility of controlled release medication formulations lies in their ability to keep drugs at steady levels in the blood plasma of recipients and within the termini of the maximum and minimum effective therapeutic levels. This avoids the “ups” and “downs” of medication levels within the body which would have been the result had conventional immediate release tablets been administered instead. In the veterinary field, controlled release medications are essential¹ because of the logistical difficulties of administering drugs on a regular (e.g., daily) basis to animals. The chief advantages of controlled release veterinary medications lie in the ease with which they can be administered; decrease in stress for animals, owing to less need for rounding up and frequent dosing; and, most importantly for farmers, the reduced cost of treatment relative to that for a multiple dosage regime.
机译：控释药物制剂的实用性在于它们能够使药物在受体的血浆中以及在最大和最小有效治疗水平的终点内保持稳定水平的能力。这样避免了体内药物水平的“上升”和“下降”，而如果使用传统的速释片剂，则可能会导致这种情况。在兽医领域，控释药物是必不可少的¹，因为定期（例如每天）对动物施用药物在后勤方面存在困难。控释兽药的主要优点在于易于管理。减少了对动物的压力，这是因为不需要进行舍入和频繁的给药；对于农民来说，最重要的是，与多剂量方案相比，降低了治疗成本。

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