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Medical proton dosimetry using radioluminescence from aluminium oxide crystals attached to optical-fiber cables

机译：使用附着在光纤电缆上的氧化铝晶体的辐射发光的医用质子剂量测定法

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The prime objective of this study is to investigate if radioluminescence (RL) from carbon-doped aluminum oxide (Al2O3:C) crystals potentially can be used for absorbed dose-rate measurements during proton radiotherapy. The RL from two separate (2 mg) Al2O3:C crystals attached to optical-fiber cables were recorded during irradiations in water in a 175 MeV clinical proton beam. The RL response for low-LET protons in the plateau region of the Bragg curve was found to closely resemble that observed for a clinical 6 MV X-ray beam. An identical response was found in the Bragg peak (where the dose-averaged LET is about 4 keV/mu m) for absorbed doses less than 0.3 Gy. For doses in the range of 0.3-3Gy, we observed a significant decrease in luminescence efficiency with LET. At 3 Gy, the luminescence efficiency was about 60% in the Bragg-peak region. The study implies that the RL-signal from Al2O3:C could potentially be suitable for medical proton dosimetry in the 0-0.3 Gy range even without any LET-dependent correction factors. (C) 2007 Elsevier B.V. All rights reserved.
机译：这项研究的主要目的是研究质子放疗过程中碳掺杂的氧化铝（Al2O3：C）晶体的放射发光（RL）是否可以用于吸收剂量率的测量。在水中以175 MeV临床质子束照射期间，记录了附着在光纤电缆上的两个单独的（2 mg）Al2O3：C晶体的RL。发现在布拉格曲线的高原区域，低LET质子的RL响应与临床6 MV X射线束观察到的相似。对于小于0.3 Gy的吸收剂量，在布拉格峰（剂量平均LET约为4 keV /μm）中发现了相同的响应。对于0.3-3Gy的剂量，我们观察到LET的发光效率显着降低。在3 Gy处，布拉格峰区域的发光效率约为60％。该研究表明，即使没有任何LET依赖性校正因子，Al2O3：C的RL信号也可能适用于0-0.3 Gy范围内的医学质子剂量测定。 （C）2007 Elsevier B.V.保留所有权利。

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