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巴戟天提取物改善或治疗性功能障碍的作用及其应用

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摘要

本发明涉及巴戟天提取物改善或治疗性功能障碍的作用及其应用，所述的治疗或改善性功能障碍物质具有通过对下丘脑-垂体-性腺及肾上腺皮质功能的整体调节来实现改善或治疗性功能障碍的作用，同时对不同的5-HT受体具有选择性的特异性，此类物质可以选择性的兴奋5-HT1受体，而对5-HT2受体和5-HT3受体无兴奋作用，可作用治疗或辅助改善性功能障碍的药物和/或食品。

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公开/公告号CN102198184A

专利类型发明专利
公开/公告日2011-09-28

原文格式PDF
申请/专利权人成都一平医药科技发展有限公司;
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申请/专利号CN201010130597.3
发明设计人张乃元;杨强;张祖兵;王雅;包旭;
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申请日2010-03-24
分类号A61K36/746;A61P15/10;A61P15/00;A23L1/29;A23L1/28;A61K31/375;A61K31/355;A61K31/4415;A61K31/51;A61K31/525;A61K31/592;A61K31/593;A61K33/04;A61K33/06;A61K125/00;
代理机构北京华科联合专利事务所;
代理人王为
地址 610041 四川省成都市人民南路四段46号锦绣花园锦华苑南楼8-2
入库时间 2023-12-18 03:21:45

法律信息

法律状态公告日

法律状态信息

法律状态
2013-05-15

发明专利申请公布后的视为撤回 IPC(主分类):A61K36/746 申请公布日:20110928 申请日:20100324

发明专利申请公布后的视为撤回
2011-11-23

实质审查的生效 IPC(主分类):A61K36/746 申请日:20100324

实质审查的生效
2011-09-28

公开

公开

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1. 巴戟天提取物改善或治疗性功能障碍的作用及其应用 [P] . 中国专利： CN102198184A . 2011-09-28
2. 一种治疗性功能障碍的中药提取物的制备方法及应用 [P] . 中国专利： CN112138035A . 2020-12-29
3. medicine to treat sexual dysfunction in a patient, medicine to treat erectile dysfunction in a patient, medicine to decrease the side effects associated with therapeutic agents to treat sexual dysfunction in a patient, method for making a medicine to treat sexual dysfunction in a patient a patient responsive marginally to the pde5 inhibitor, and use of the peptide ac-nle-cycle (-asp-his-d-phe-arg-trp-lys) -0h in the preparation of a medication [P] . BRPI0510862A . 2007-12-26

机译：治疗患者性功能障碍的药物，治疗患者的勃起功能障碍的药物，减少与治疗患者的性功能障碍的治疗剂相关的副作用的药物，制备治疗患者的性功能障碍的药物的方法仅对pde5抑制剂有反应，并在制备药物时使用肽ac-nle-cycle（-asp-his-d-phe-arg-trp-lys）-0h
4. spirocyclic heterocyclic compound, pharmaceutical composition, method to bind opioid receptors, methods to prevent or treat pain, gastrointestinal dysfunction, a urogenital tract disorder, an immunomodulatory disorder, an inflammatory disorder, a respiratory function disorder, anxiety, mood disorder, a stress-related disorder, sympathetic nervous system disorder, cough, and a motor disorder, method for treating traumatic injury to the central nervous system, methods for preventing or treating stroke, cardiac arrhythmia, glaucoma, and sexual dysfunction, methods for treating a condition selected from the group consisting of shock, cerebral edema, cerebral ischemia, cerebral deficit after cardiac surgery (bypass) and graft, systemic lupus erythematosus, hodgkin's disease, sjogren's disease, epilepsy, and rejection in organ transplants and skin grafts, and to treat substance dependence, method to improve organ and cell survival, and cardioprotection after myocardial infarction, methods to [P] . BRPI0415165A . 2007-01-09

机译：螺环杂环化合物，药物组合物，阿片受体的结合方法，预防或治疗疼痛，胃肠道功能障碍，泌尿生殖道疾病，免疫调节疾病，炎性疾病，呼吸功能疾病，焦虑症，情绪障碍，与压力有关的方法疾病，交感神经系统疾病，咳嗽和运动障碍，治疗中枢神经系统创伤的方法，预防或治疗中风，心律不齐，青光眼和性功能障碍的方法，治疗选自以下组的疾病的方法包括休克，脑水肿，脑缺血，心脏手术（旁路）和移植后脑缺损，系统性红斑狼疮，霍奇金病，干燥综合征，癫痫和器官移植和皮肤移植排斥反应，以及治疗药物依赖的方法改善器官和细胞存活率以及心肌梗死后的心脏保护作用，
5. In view of their capability to antagonize the actions of neurokinins by blocking the neurokinin receptors, and in particular antagonizing the actions of substance P by blocking the NK1 receptor, the compounds according to the invention are useful as a medicine, in particular in the prophylactic and therapeutic treatment of neurokinin-mediated conditions, such as, for instance CNS disorders, in particular depression, anxiety disorders, stress-related disorders, sleep disorders, cognitive disorders, personality disorders, schizoaffective disorders, eating disorders, neurodegenerative diseases, addiction disorders, mood disorders, sexual dysfunction, pain and other CNS-related conditions; inflammation; allergic disorders; emesis; gastrointestinal disorders, in particular irritable bowel syndrome (IBS); skin disorders; vasospastic diseases; fibrosing and collagen diseases; disorders related to immune enhancement or suppression and rheumatic diseases and body weight control. [P] . EA009217B1 . 2007-12-28

机译：考虑到它们通过阻断神经激肽受体来拮抗神经激肽的作用，特别是通过阻断NK1受体来拮抗P物质的作用的能力，根据本发明的化合物可用作药物，特别是在预防和治疗中。治疗神经激肽介导的疾病，例如中枢神经系统疾病，尤其是抑郁症，焦虑症，与压力有关的疾病，睡眠障碍，认知障碍，人格障碍，精神分裂性障碍，进食障碍，神经退行性疾病，成瘾障碍，情绪疾病，性功能障碍，疼痛和其他中枢神经系统相关疾病;炎;过敏性疾病呕吐胃肠道疾病，特别是肠易激综合症（IBS）;皮肤疾病;血管痉挛性疾病;纤维化和胶原蛋白疾病;与免疫增强或抑制，风湿性疾病和体重控制有关的疾病。