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Recombinant vector for producing animal model with cardiac hypertrophy, transformed model with cardiac hypertrophy by the recombinant vector and a method of production thereof
Recombinant vector for producing animal model with cardiac hypertrophy, transformed model with cardiac hypertrophy by the recombinant vector and a method of production thereof
The present invention relates to a recombinant vector for producing an animal model of cardiomegaly, an animal model of cardiomegaly transformed with the recombinant vector, and a method for manufacturing the recombinant vector according to the present invention, when the recombinant vector according to the present invention is specifically expressed in mouse myocardial cells, By recognizing and suppressing only the non-regular G: A wobble nucleotide sequence target site of the microRNA, a biological function of increasing the size of the myocardial cells appears, thereby leading to hypertrophy, thereby producing an animal model in which hypertrophy is induced. Therefore, it is expected to be useful for research on the progress, pathology, and physiological mechanisms of heart disease including hypertrophy at the individual level.
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