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A new approach of dynamic pinhole SPECT imaging for evaluation of sympathetic nervous system function in animal models of cardiac hypertrophy

机译：动态针孔SPECT成像评估心脏肥大动物模型中交感神经系统功能的新方法

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Typically /sup 123/I-MIBG is used for the study of innervation and function of the sympathetic nervous system in heart failure. The protocol involves two studies: first a planar or SPECT scan is performed to measure initial uptake of the tracer, followed some 3-4 hours later by another study measuring the wash-out of the tracer from the heart. A fast wash-out is indicative of a compromised heart. In this work, a dual head pinhole SPECT system was used for imaging the distribution and kinetics of /sup 123/I-MIBG in the myocardium of spontaneous hypertensive rats (SHR) and normotensive Wistar Kyoto (WKY) rats. The system geometry was calibrated based on a nonlinear point projection fitting method using a three-point source phantom. The angle variation effect of the parameters was modeled with a sinusoidal function. A dynamic acquisition was performed by injecting /sup 123/I-MIBG into rats immediately after starting the data acquisition. The detectors rotated continuously traversing 360/spl deg/ every 90 seconds. We applied the FADS method to obtain time activity curves in the blood pool and myocardium. Since the initial injection bolus is too fast to obtain a consistent tomographic data set in the first minute of the study, we applied the FADS method directly to projections during the first rotation. In the future, the method will be applied to determine if there are differences in the kinetics between SHR and WKY rats. This approach requires less time by replacing the delayed scan at 3-4 hours after injection with a dynamic acquisition of 90 to 120 minutes.
机译：通常，/ sup 123 / I-MIBG用于研究心力衰竭中交感神经系统的神经支配和功能。该方案涉及两项研究：首先进行平面或SPECT扫描以测量示踪剂的初始摄取，然后大约3-4小时后进行另一项测量，以从心脏中清除示踪剂。快速冲洗表明心脏受损。在这项工作中，使用双头针孔SPECT系统对自发性高血压大鼠（SHR）和血压正常的Wistar Kyoto（WKY）大鼠心肌中/ sup 123 / I-MIBG的分布和动力学进行成像。基于使用三点源体模的非线性点投影拟合方法，对系统几何进行了校准。使用正弦函数对参数的角度变化效果进行建模。在开始数据采集后立即将/ sup 123 / I-MIBG注入大鼠体内进行动态采集。检测器每90秒连续旋转360 / spl deg /。我们应用FADS方法来获得血池和心肌中的时间活动曲线。由于最初的注射推注速度太快，无法在研究的第一分钟获得一致的断层扫描数据集，因此我们在第一次旋转期间将FADS方法直接应用于投影。将来，该方法将用于确定SHR和WKY大鼠之间的动力学差异。这种方法通过用90至120分钟的动态采集代替注射后3-4小时的延迟扫描，从而减少了时间。

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