首页>
外国专利>
RECOMBINANT VECTOR FOR PRODUCING CARDIAC HYPERTROPHY ANIMAL MODEL, CARDIAC HYPERTROPHY ANIMAL MODEL TRANSFORMED WITH RECOMBINANT VECTOR, AND PRODUCTION METHOD THEREFOR
RECOMBINANT VECTOR FOR PRODUCING CARDIAC HYPERTROPHY ANIMAL MODEL, CARDIAC HYPERTROPHY ANIMAL MODEL TRANSFORMED WITH RECOMBINANT VECTOR, AND PRODUCTION METHOD THEREFOR
展开▼
机译:用于生产心脏肥大动物模型的重组载体,用重组载体转化的心脏肥大动物模型及其生产方法
展开▼
页面导航
摘要
著录项
相似文献
摘要
The present invention relates to a recombinant vector for producing a cardiac hypertrophy animal model, a cardiac hypertrophy animal model transformed with the recombinant vector, and a production method therefor. When a recombinant vector according to the present invention is specifically expressed in mouse cardiomyocytes, only non-canonical G:A wobble base sequence target sites of miRNA are recognized and inhibited, so that a biological function of increasing the size of cardiomyocytes is exhibited so as to induce cardiac hypertrophy, and thus an animal model in which cardiac hypertrophy has been induced is expected to be produced so as to be effectively used for studying the progression, pathology and physiological mechanism of heart diseases including cardiac hypertrophy at the individual level.
展开▼