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BETA-CARBOLINES AS POSITIVE ALLOSTERIC MODULATORS OF THE HUMAN SEROTONIN RECEPTOR 2C (5-HT2C)
BETA-CARBOLINES AS POSITIVE ALLOSTERIC MODULATORS OF THE HUMAN SEROTONIN RECEPTOR 2C (5-HT2C)
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机译：β-碳水化合物作为人类5-羟色胺受体2C（5-HT 2C ）的正变构调节剂
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摘要
Disclosed are novel small molecules, methods of synthesis of the small molecules, and uses of the small molecules for modulating activity of the human serotonin receptor 2C (5-HT2c), preferably selectively. The small molecules have a substituted beta-carboline core structure, which optionally may be saturated at one or more bonds to provide a dihydro-beta-carboline core or a tetrahydro-beta-carboline core. The small molecules may be administered to treat and/or prevent diseases, disorders, and/or conditions associated with human serotonin receptor 2C (5- HT2C) including psychiatric, mental, and/or neurological diseases, disorders, and conditions such as cognitive impairment, addiction, and obsessive compulsive disorder. The disclosed small molecules also may be administered to treat and/or prevent obesity, for example, via appetite suppression.
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