首页> 外国专利> COMBINATION OF mRNA EXPRESSION LEVELS OF DLX1 AND HOXC6 IN URINE AS MOLECULAR MARKERS IN PROSTATE CANCER

COMBINATION OF mRNA EXPRESSION LEVELS OF DLX1 AND HOXC6 IN URINE AS MOLECULAR MARKERS IN PROSTATE CANCER

机译：尿中DLX1和HOXC6的mRNA表达水平作为前列腺癌分子标记的结合

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摘要

The present invention relates to methods for diagnosing prostate cancer and especially diagnosing LG, HG, PrCa Met and CRPC. Specifically, the present invention relates to methods for in vitro diagnosing prostate cancer in a human individual comprising: 1) determining the expression of one or more genes chosen from the group consisting of ACSM1, ALDH3B2, CGREF1, COMP, C19orf48, DLX1, GLYATL1, MS4A8B, NKAIN1, PPFIA2, PTPRT, TDRD1 and/or UGT2B15; and 2) establishing up regulation of expression of said one or more genes as compared to expression of the respective one or more genes in a sample from an individual without prostate cancer thereby providing said diagnosis of prostate cancer.

机译：本发明涉及诊断前列腺癌的方法，尤其是诊断LG，HG，PrCa Met和CRPC的方法。具体而言，本发明涉及用于在人类个体中体外诊断前列腺癌的方法，该方法包括：1）确定一种或多种选自以下的基因的表达：ACSM1，ALDH3B2，CGREF1，COMP，C19orf48，DLX1，GLYATL1， MS4A8B，NKAIN1，PPFIA2，PTPRT，TDRD1和/或UGT2B15;和2）与来自没有前列腺癌的个体的样品中的所述一种或多种基因的表达相比，建立所述一种或多种基因的表达的调节，从而提供对前列腺癌的所述诊断。

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公开/公告号US2020165684A1

专利类型
公开/公告日2020-05-28

原文格式PDF
申请/专利权人 MDXHEALTH RESEARCH B.V.;
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申请/专利号US201916585876
发明设计人 FRANCISCUS PETRUS SMIT;JACK A. SCHALKEN;DAPHNE HESSELS;
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申请日2019-09-27
分类号C12Q1/6886;
国家 US
入库时间 2022-08-21 11:21:51

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