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Regulatory T cells, regulatory B cells, and method of regulating immune response using modulator of APRIL-TACI interaction

机译:调节性T细胞,调节性B细胞以及使用APRIL-TACI相互作用调节剂调节免疫应答的方法

摘要

The present invention is based, in part, on regulatory T cells, regulatory B cells, and methods of modulating immune responses using modulators of the APRIL-TACI interaction. A method for selectively modifying the number and/or inhibitory immune activity of regulatory T cells (Treg) and/or regulatory B cells (Breg) in a subject, the TACI receptor being expressed by said Treg and/or Breg A therapeutically effective amount of at least one agent that modifies the interaction of a protein with an APRIL ligand such that the number and/or inhibitory immune activity of said Treg and/or Breg is selectively modified. The method comprising administering to the subject. [Selection diagram] Figure 1
机译:本发明部分地基于调节性T细胞,调节性B细胞以及使用APRIL-TACI相互作用的调节剂来调节免疫应答的方法。一种选择性改变受试者中调节性T细胞(Treg)和/或调节性B细胞(Breg)的数量和/或抑制性免疫活性的方法,所述TACI受体由所述Treg和/或Breg表达。至少一种修饰蛋白质与APRIL配体相互作用的试剂,从而选择性地修饰所述Treg和/或Breg的数量和/或抑制性免疫活性。该方法包括对受试者给药。 [选型图]图1

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