首页> 外国专利> LINE OF MICE TRANSGENIC ON AN ALPHA-CHAIN OF A T-CELL RECEPTOR OF MEMORY CELLS, TO STUDY THEIR FUNCTIONAL ACTIVITY

LINE OF MICE TRANSGENIC ON AN ALPHA-CHAIN OF A T-CELL RECEPTOR OF MEMORY CELLS, TO STUDY THEIR FUNCTIONAL ACTIVITY

机译:记忆细胞T细胞受体α链上的小鼠转基因系,以研究其功能活性

摘要

FIELD: biotechnology.;SUBSTANCE: invention relates to molecular biotechnology, in particular to a cassette vector comprising a full-length cDNA of an alpha chain of a T-cell receptor of memory cells, a method of producing said vector, as well as a method for producing a line of mice transgenic on an alpha chain of a T-cell receptor of memory cells.;EFFECT: invention makes it possible to create lines of genetically modified mice, containing in their genome rearranged gene locus of alpha chain of TCR memory cells with specificity to histocompatibility molecule H-2Kb.;4 cl, 8 ex, 3 dwg
机译:技术领域本发明涉及分子生物技术,特别是涉及包含记忆细胞的T细胞受体的α链的全长cDNA的盒载体,该载体的生产方法以及其制备方法。产生在记忆细胞的T细胞受体的α链上转基因的小鼠品系的方法;效果:本发明使得可以创建转基因小鼠的品系,其基因组中含有TCR记忆的α链的重排基因座对组织相容性分子H-2K b 具有特异性的细胞; 4 cl,8 ex,3 dwg

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