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ROLE OF EXOSOMES, EXTRACELLULAR VESICLES, IN THE REGULATION OF METABOLIC HOMEOSTASIS
ROLE OF EXOSOMES, EXTRACELLULAR VESICLES, IN THE REGULATION OF METABOLIC HOMEOSTASIS
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机译:外体组,细胞外血管在代谢稳态中的作用
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摘要
A method is described for regulating metabolic homeostasis in a subject in need thereof, the method comprising isolating circulating exosomes from a healthy donor, and administering the exosomes to the subject, under conditions sufficient to regulate metabolic homeostasis in the subject, wherein the exosomes act by a direct interaction with insulin target tissues and/or by modulation of immune function. Furthermore, the components of the exosomes, such as RNAs and/or products catalyzed by sphingomyelin phosphodiesterase 3 (SMPD3) are used to treat metabolic disorders, such as insulin resistance and type 2 diabetes. In addition, a method for early detection of metabolic risks associated with obesity is provided.
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