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METHOD FOR LIQUID CHROMATOGRAPHIC MASS SPECTROMETRY AND LIQUID CHROMATOGRAPH MASS SPECTROMETER

机译：液相色谱质谱法和液相色谱质谱仪

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摘要

In an LC/MS analysis of a sample containing various compounds, additive supply pumps 164A and 164B in a post-column adding unit 16 draw and supply different kinds of additives A and B from containers 163A and 163B, respectively. The additives are mixed into an eluate through T-joints 162 and 161. A preferable combination of the additives is the combination of DMSO which produces the effect of gathering charge states and 2-propanol which produces the effect of promoting atomization or vaporization of droplets. By mixing the two additives into the eluate while mixing them at an appropriate flow-rate ratio according to a previously determined flow-rate program, the ionization efficiency can be nearly optimized for each compound during the process of generating ions by spraying electrically charged droplets of the eluate from an ESI spray 21. Consequently, the detection sensitivity becomes higher than conventional levels.

机译：在对包含各种化合物的样品进行LC / MS分析时，在柱后添加单元 16 中使用添加剂供应泵 164 A和 164 B从容器 163 A和 163 B分别抽取和供应不同种类的添加剂A和B。添加剂通过T型接头 162 和 161混合到洗脱液中。添加剂的优选组合是DMSO的组合，可产生聚集电荷态和2 -丙醇，具有促进液滴雾化或汽化的作用。通过将两种添加剂混合到洗脱液中，同时根据事先确定的流速程序将它们以合适的流速比混合，可以在通过喷雾带电液滴的方式产生离子的过程中，使每种化合物的电离效率几乎达到最佳。 ESI喷雾 21 的洗脱液。因此，检测灵敏度变得比常规水平更高。 展开▼

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公开/公告号US2018328898A1

专利类型

公开/公告日2018-11-15

原文格式PDF

申请/专利权人 SHIMADZU CORPORATION;
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申请/专利号US201815973640

发明设计人 YUSAKU HIOKI;
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申请日2018-05-08

分类号G01N30/38;G01N30/84;G01N30/72;G01N30/28;H01J49/16;G01N33/68;

国家 US

入库时间 2022-08-21 12:06:27

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