;The binding agent can be a binding protein, an antibody, or an aptamer, and the analyte can be a biomolecule. Accordingly, the current invention provides a method of detecting the presence or assessing the likelihood of development of a disease associated with an abnormal level of a biomolecule in a subject."/>
Label-free electrochemical biosensor
The current invention pertains to electrochemical biosensors. The electrochemical biosensor of the current invention comprises:a) a sensing electrode having attached to its surface a binding agent capable of specifically binding to the analyte to form a binding agent-analyte complex and wherein the binding of the analyte to the binding agent alters the electron transfer properties at the sensing electrode surface thereby providing a change in the electrochemical response at the sensing electrode surface proportional to the number of binding agent-analyte complexes, andb) a test equipment capable of measuring the electrochemical response at the sensing electrode surface.;The binding agent can be a binding protein, an antibody, or an aptamer, and the analyte can be a biomolecule. Accordingly, the current invention provides a method of detecting the presence or assessing the likelihood of development of a disease associated with an abnormal level of a biomolecule in a subject.
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机译：本发明涉及电化学生物传感器。本发明的电化学生物传感器包括： a）感测电极，其表面附着有能够与分析物特异性结合的结合剂，从而形成结合剂-分析物复合物，并且其中分析物与结合剂的结合改变了电子转移性能在感测电极表面上，从而在感测电极表面上提供与粘合剂-分析物络合物数量成正比的电化学响应变化，并且 b ）一种能够测量感应电极表面电化学响应的测试设备。 ;结合剂可以是结合蛋白，抗体或适体，并且被分析物可以是生物分子。因此，本发明提供了一种检测受试者中与生物分子异常水平有关的疾病的存在或评估其发展可能性的方法。
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