首页> 外国专利> Method for producing biocompatible porcine cartilage-derived extracellular matrix membrane capable of controlling biodegradation rate and physical properties, and composition for preventing adhesion comprising the porcine cartilage-derived extracellular matrix as an active ingredient

Method for producing biocompatible porcine cartilage-derived extracellular matrix membrane capable of controlling biodegradation rate and physical properties, and composition for preventing adhesion comprising the porcine cartilage-derived extracellular matrix as an active ingredient

机译:能够控制生物降解速度和物理性质的生物相容性猪软骨来源的细胞外基质膜的制备方法和防止粘连的组合物,其包含猪软骨来源的细胞外基质作为活性成分

摘要

The present invention relates to a method for producing a biocompatible porcine cartilage-to-extracellular matrix membrane capable of controlling the biodegradation rate and physical properties, and a composition for preventing adhesion comprising the porcine cartilage-to-extracellular matrix as an active ingredient. In spite of the high biocompatibility as a natural raw material, the cartilage tissue extracellular matrix has weak physical properties such as a short degradation period and there is a limit to its application, so physical properties or chemical treatments Developed a way to improve Kind Code: A1 In the present invention, porcine cartilage-derived extracellular matrix is treated by a physicochemical method to manufacture biomaterials of various dosage forms. In addition, despite the physico-chemical treatment, the characteristics of maintaining the cartilage-specific function as described above were confirmed. In addition, porcine cartilage-derived extracellular matrix material can also be used as an adhesion prevention agent excellent in internal safety and adhesion prevention effect. [Selected figure] Figure 1
机译:本发明涉及一种能够控制生物降解速度和物理性质的生物相容性猪软骨-细胞外基质膜的制备方法,以及一种以猪软骨-细胞外基质为有效成分的防止粘连的组合物。尽管作为天然原料具有很高的生物相容性,但软骨组织细胞外基质的物理性质较弱,例如降解期短,其应用受到限制,因此,物理性质或化学处理已开发出一种改进种类代码的方法: A1在本发明中,通过物理化学方法处理猪软骨来源的细胞外基质,以制备各种剂型的生物材料。另外,尽管进行了物理化学处理,仍确认了如上所述保持软骨特异性功能的特征。另外,猪软骨来源的细胞外基质材料也可以用作内部安全性和防粘连效果优异的防粘连剂。 [选定图]图1

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