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A PROCESS FOR DETERGENT-FREE PRODUCTION OF OUTER MEMBRANE VESICLES OF A GRAM-NEGATIVE BACTERIUM

机译:革兰氏阴性菌外膜囊泡无毒生产的过程

摘要

The present invention relates to the fields of medical microbiology and vaccines. In particular the invention relates to a process for detergent-free preparation of outer membrane vesicles (OMV) of Gram negative bacteria for use in vaccines, to OMV obtainable by said process, and to a pharmaceutical composition comprising such OMV. The present invention further relates to the use of OMV of the present invention as a medicament in particular for use in a method for eliciting an immune response.
机译:本发明涉及医学微生物学和疫苗领域。特别地,本发明涉及用于疫苗中的革兰氏阴性细菌的外膜囊泡(OMV)的无洗涤剂制备的方法,通过所述方法可获得的OMV以及包含这种OMV的药物组合物。本发明进一步涉及本发明的OMV作为药物的用途,特别是用于引发免疫应答的方法中。

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