首页> 外国专利> VACCINE AGAINST ANKARA RECOMBINANT MODIFIED VACCINIA VACCINIA VIRUS (MVA)?

VACCINE AGAINST ANKARA RECOMBINANT MODIFIED VACCINIA VACCINIA VIRUS (MVA)?

机译：对抗安卡拉重组疫苗的疫苗疫苗病毒（MVA）？

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摘要

The present invention relates to an improved filovirus vaccine comprising a recombinant modified ankara (mva-based) vaccinia virus vaccine against filovirus infection and related products, methods and uses. specifically, the present invention relates to genetically engineered mva and fpv (recombinant) vectors comprising at least one heterologous nucleotide sequence encoding an antigenic determinant of a marburg virus (marv) or ebola virus glycoprotein. specifically, the invention relates to recombinant mva comprising ebola virus glycoprotein and virion protein 40. the invention also relates to products, methods and uses thereof, as well as genetically engineered mva and fpv (recombinant) initiation / boost regimens, for example, suitable for inducing a protective immune response in a subject.

机译：本发明涉及改进的丝状病毒疫苗，其包含针对丝状病毒感染的重组修饰的安卡拉（基于mva的）牛痘病毒疫苗以及相关产品，方法和用途。具体而言，本发明涉及基因工程的mva和fpv（重组）载体，其包含至少一个编码马尔堡病毒（marv）或埃博拉病毒糖蛋白的抗原决定簇的异源核苷酸序列。具体而言，本发明涉及包含埃博拉病毒糖蛋白和病毒粒子蛋白40的重组mva。本发明还涉及其产品，方法和用途，以及基因工程mva和fpv（重组）起始/加强方案，例如，适用于在受试者中诱导保护性免疫应答。

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公开/公告号BR112017003908A2

专利类型
公开/公告日2018-02-27

原文格式PDF
申请/专利权人 BAVARIAN NORDIC A/S;
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申请/专利号BR20171103908
发明设计人 ARIANE VOLKMANN;HENNING LAUTERBACH;HUBERTUS HOCHREIN;JÜRGEN HAUSMANN;ROBIN STEIGERWALD;ULRIKE DIRMEIER;
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申请日2015-09-03
分类号A61K39/12;
国家 BR
入库时间 2022-08-21 12:53:52

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