Phase contrast microscope, phase contrast microscope control apparatus, and phase contrast microscope control method

• 1. 一种相衬显微镜及其调试方法 [P] . 中国专利： CN109633882B . 2021.01.05
• 2. 组合式明视场和相衬显微镜系统及配备其的图像处理设备 [P] . 中国专利： CN110709749B . 2021.10.26
• 3. Phase contrast microscope, phase contrast microscope control apparatus, and phase contrast microscope control method [P] . 日本专利： JPWO2014091661A1 . 2017-01-05

  机译： 相衬显微镜，相衬显微镜控制装置以及相衬显微镜控制方法

• 4. PHASE CONTRAST MICROSCOPE, CONTROL APPARATUS FOR PHASE CONTRAST MICROSCOPE, AND CONTROL METHOD FOR PHASE CONTRAST MICROSCOPE [P] . 美国专利： US2015309296A1 . 2015-10-29

  机译： 相衬显微镜，相衬显微镜的控制装置以及相衬显微镜的控制方法

• 5. PHASE-CONTRAST MICROSCOPE, CONTROL DEVICE FOR PHASE-CONTRAST MICROSCOPE, AND CONTROL METHOD FOR PHASE-CONTRAST MICROSCOPE [P] . 世界知识产权组织专利： WO2014091661A1 . 2014-06-19

  机译： 相衬显微镜，相衬显微镜的控制装置和相衬显微镜的控制方法

• 1. An Improved Phase Retrieval Algorithm for X-ray In-line Phase-Contrast Imaging [J] . GUO Yun-feng, ZHUANG Tian-ge, SUN Jian-qi 中国生物医学工程学报（英文版） . 2016,第002期
• 2. Algorithm for phase contrast X-ray tomography based on nonlinear phase retrieval [J] . NI Wen-lei, ZHOU Tie 应用数学和力学（英文版） . 2008,第001期
• 3. Growth Phases of Mycoplasma in Liquid Media Observed with Phase-Contrast Microscope [J] . Shmuel Razin, Benjamin J. Cosenza Journal of bacteriology . 1966,第2期
• 4. Molecular contrast on phase-contrast microscope [J] . Keiichiro Toda, Miu Tamamitsu, Yu Nagashima, Scientific reports. . 2019,第1期
• 5. Re-evaluation of differential phase contrast (DPC) in a scanning laser microscope using a split detector as an alternative to differential interference contrast (DIC) optics [J] . Amos WB., Reichelt S., Cattermole DM., Journal of Microscopy . 2003,第Pta2期
• 6. Cell extraction method from time-series image of phase contrast microscope [C] . Masaki Tamura, Toshiyuki Tanaka International Conference on Computer Application Technologies . 2015
• 7. Characterization of secondary phases in Cd0.9Zn 0.1Te detector grade semiconductor by IR transmission microscope and implementation of ampoule rotation technique in modified vertical Bridgman growth to minimize the secondary phases. [D] . Bhaladhare, Sachin. 2013
• 8. Growth Phases of Mycoplasma in Liquid Media Observed with Phase-Contrast Microscope [O] . Shmuel Razin, Benjamin J. Cosenza 1966
• 9. The Comparison of The Oral Micro-Organism Examined Through the Phase-Contrast Microscope and Gene Analysis PCR Method for Dental Implant Patients [O] . Yeon Soo Chang 2019
• 10. Image contrast and phase modulated light methods in polarization and inteference microscopy. Instruction manual for the PAR EPM-1 photoelectric polarizing and interference microscope [R] . Allen, R. D. 1964

• 1. Phases-Controlled Coordinated Charging Method for Electric Vehicles [J] . Chenglin Liao ,Bing Yang . 中国电工技术学会电机与系统学报(英文) . 2018,第1期
• 2. BACKGROUND： Vibrio vulnifi cus inside the body could activate the NF-!B signaling pathwayand initiate the inflammatory cascade. The lung is one of the earliest organs affected by sepsisassociated with acute lung injury. High mobility group protein B1 （HMGB1） is an important late-actingpro-infl ammatory cytokine involving in the pathophysiology of sepsis. It is also involved in the injuryprocess in the lung, liver and intestine. There has been no report on the involvement of HMGB1 inVibrio vulnifi cus sepsis-induced lung injury.METHODS： Sixty rats were randomly divided into a normal control group （group A, n=10） anda Vibrio vulnificus sepsis group （group B, n=50）. Sepsis was induced in the rats by subcutaneousinjection of Vibrio vulnificus （concentration 6×108 cfu/mL, volume 0.1 mL/100g）） into the left lowerlimbs. The rats in group B were sacrifi ced separately 1, 6, 12, 24, and 48 hours after the infection.Their lungs were stored as specimens, lung water content was measured, and lung pathology wasobserved under a light microscope. The expressions of the HMGB1 gene and protein in the lungswere detected by RT-PCR and Western blot. Data were analyzed with one-way analysis of variance（ANOVA） and the LSD method for pair-wise comparison between the two groups. P〈0.05 wasconsidered statistically signifi cant.RESULTS： Compared to group A （0.652±0.177）, HMGB1 mRNA expression in the lungs ofgroup B was signifi cantly higher at 0 hour （1.161±0.358, P=0.013）, 24 hours （1.679±0.235, P=0.000）,and 48 hours （1.258±0.274, P=0.004） （P〈0.05）, and peaked at 24 hours. Compared to group A（0.594±0.190）, HMGB1 protein expression at 6 hours （1.408±0.567, P=0.026） after infection wassignificantly increased （P〈0. 05）, and peaked at 24 hours （2.415±1.064, P=0.000） after infection.Compared to group A （0.699±0.054）, lung water content was significantly increased at 6 hours（0.759±0.030, P=0.001）,12 hours （0.767±0.023, P=0.000）, 24 hours （0.771±0.043, P=0.000） and 48hours （0.789±0.137, P=0.000） after infection （P〈0.05）. Compared to group A, pathological changesat 12 hours in group B indicate marked pulmonary vascular congestion, interstitial edema andinfl ammatory infi ltration. Alveolar cavity collapse and boundaries of the alveolar septum could not beclearly identifi ed.CONCLUSION： Vibrio vulnifi cus sepsis can lead to injury in rat lungs, and increased HMGB1expression in lung tissue may be one of the mechanisms for injury from Vibrio vulnifi cus sepsis. [J] . Qiao-meng Qiu ,Zhong-wang Li ,Lu-ming Tang . 世界急诊医学杂志(英文) . 2011,第4期
• 3. Coherent confocal microscope with a phase-only filter in its extended source [J] . YANG Chu-ping . 光电子快报：英文版 . 2006,第2期
• 4. 泽尼克的相衬法与相衬显微镜 [C] . 刘辛味 . 第六届北京地区“科史哲”研究生学术论坛 . 2015
• 5. 微分干涉相衬金相显微镜Nomarski棱镜设计 [A] . 徐小岚 . 2014