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Method for Determing Scrub Typhus Using measurement Interferon-Gamma Secretion of Peripheral Blood Mononuclear Cells
Method for Determing Scrub Typhus Using measurement Interferon-Gamma Secretion of Peripheral Blood Mononuclear Cells
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机译:测定外周血单个核细胞干扰素-γ分泌的测定斑疹伤寒的方法
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摘要
The present invention relates to a diagnostic method for scrub typhus using interferon-gamma (IFN-) secretion measurement of peripheral blood mononuclear cells (PBMC), and more particularly to a method for diagnosing Tsutsugamushi disease In the case of peripheral blood mononuclear cells isolated from the blood of a patient infected with Tsutsugamushi bacteria, treatment with an extract of Tsutsugamushi extract to induce INF- production is increased, whereas INF- production does not change in non-infected peripheral blood mononuclear cells Therefore, it is possible to diagnose Tsutsugamushi disease simply by measuring the INF-y production concentration. Furthermore, the method for diagnosing Tsutsugamushi disease of the present invention can be applied to indirect immunofluorescence for the diagnosis of Tsutsugamushi disease and PCR analysis for genotyping The accuracy of the diagnosis is remarkably improved, and it is possible to completely replace the conventional diagnostic method It shall thereby significantly improving the reliability of the diagnosis.;
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