首页> 外国专利> Method for Determing Scrub Typhus Using measurement Interferon-Gamma Secretion of Peripheral Blood Mononuclear Cells

Method for Determing Scrub Typhus Using measurement Interferon-Gamma Secretion of Peripheral Blood Mononuclear Cells

机译:测定外周血单个核细胞干扰素-γ分泌的测定斑疹伤寒的方法

摘要

The present invention relates to a diagnostic method for scrub typhus using interferon-gamma (IFN-) secretion measurement of peripheral blood mononuclear cells (PBMC), and more particularly to a method for diagnosing Tsutsugamushi disease In the case of peripheral blood mononuclear cells isolated from the blood of a patient infected with Tsutsugamushi bacteria, treatment with an extract of Tsutsugamushi extract to induce INF- production is increased, whereas INF- production does not change in non-infected peripheral blood mononuclear cells Therefore, it is possible to diagnose Tsutsugamushi disease simply by measuring the INF-y production concentration. Furthermore, the method for diagnosing Tsutsugamushi disease of the present invention can be applied to indirect immunofluorescence for the diagnosis of Tsutsugamushi disease and PCR analysis for genotyping The accuracy of the diagnosis is remarkably improved, and it is possible to completely replace the conventional diagnostic method It shall thereby significantly improving the reliability of the diagnosis.;
机译:本发明涉及一种使用干扰素-γ(IFN-)分泌测定外周血单核细胞(PBMC)来擦伤斑疹伤寒的诊断方法,更具体地,涉及在从中分离出的外周血单核细胞的情况下的disease虫病的诊断方法。感染Tsu虫病患者的血液后,用gam虫病提取物的提取物进行处理以诱导INF的产生增加,而未感染的外周血单核细胞中INF的产生不变,因此,可以简单地诊断Tsu虫病通过测量INF-y的生产浓度。此外,本发明的Tsu虫病的诊断方法可以应用于间接免疫荧光法来诊断Tsu虫病和PCR分析以进行基因分型。从而显着提高诊断的可靠性。

著录项

  • 公开/公告号KR20170079139A

    专利类型

  • 公开/公告日2017-07-10

    原文格式PDF

  • 申请/专利权人 인하대학교 산학협력단;

    申请/专利号KR20150189371

  • 发明设计人 이진수;

    申请日2015-12-30

  • 分类号G01N33/68;C07K16/24;C12N5/0783;G01N15/14;G01N33/543;

  • 国家 KR

  • 入库时间 2022-08-21 13:27:05

相似文献

  • 专利
  • 外文文献
  • 中文文献
获取专利

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号