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compound, pharmaceutical composition, use of the compound, method for treating a malignant tumor, c-met autophosphorylation inhibitor, and hgf / c-met signal transduction screening agent
compound, pharmaceutical composition, use of the compound, method for treating a malignant tumor, c-met autophosphorylation inhibitor, and hgf / c-met signal transduction screening agent
An objective of the present invention is to provide compounds having antitumor activity. According to the present invention, there is provided compounds represented by formula (I) and pharmaceutically acceptable salts thereof, and solvates thereof: wherein R 1 represents H or a substitutable unsaturated five- or six-membered heterocyclic ring; R 2 represents H; X represents CH or N; Z represents O or S; E is absent or represents halogen, alkyl, or alkoxy; J represents S or O; and T represents phenyl, an unsaturated five- or six-membered heterocyclic ring, an unsaturated nine- or ten-membered bicyclic carbocyclic ring or heterocyclic ring.
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机译：本发明的目的是提供具有抗肿瘤活性的化合物。根据本发明，提供了由式（I）表示的化合物及其药学上可接受的盐及其溶剂化物：其中R 1代表H或可取代的不饱和五元或六元杂环; R 2代表H; X代表CH或N; Z代表O或S; E不存在或代表卤素，烷基或烷氧基; J代表S或O; T表示苯基，不饱和五元或六元杂环，不饱和九元或十元双环碳环或杂环。
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