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Novel compounds of 11β-hydroxysteroids for use in diseases associated with mitochondrial biogenesis and mitochondrial dysfunction or deficiency

机译：用于与线粒体生物发生和线粒体功能障碍或缺乏症有关的疾病的11β-羟基类固醇的新型化合物

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摘要

The present invention relates to novel compounds and compositions of 11β-hydroxy steroids and pharmaceuticals for preventing or reversing mitochondrial damage in human or animal subjects, to treat or prevent diseases associated with mitochondrial dysfunction or deficiency Provided are pharmaceuticals and their application as pharmaceuticals to induce mitochondrial regeneration or reconstitution as a means of treating diseases associated with abnormal mitochondrial structure and function. Also disclosed herein are methods for diagnosing mitochondrial damage and methods for diagnosing the success or failure of therapeutic agents designed to treat, prevent, or reverse mitochondrial damage or deficiency. [Selection figure] None

机译：本发明涉及11β-羟基类固醇的新型化合物和组合物以及用于预防或逆转人或动物受试者的线粒体损伤，以治疗或预防与线粒体功能障碍或缺乏症有关的疾病的药物。再生或重建，作为治疗与异常线粒体结构和功能有关的疾病的手段。本文还公开了用于诊断线粒体损伤的方法和用于设计，治疗或预防或逆转线粒体损伤或缺陷的治疗剂的成功或失败的方法。 [选择图]无

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公开/公告号JP2016505038A

专利类型
公开/公告日2016-02-18

原文格式PDF
申请/专利权人スファエラファーマプライベートリミテッド;
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申请/专利号JP20150553230
发明设计人ドゥガル;サンディープ;シュレイナー;フレデリック;ジョージ;マハジャン;ディネッシュ;シャルマ;アミット;パティル;イシュワール;ラケッシュ;クイラ;ビラッシュ;
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申请日2014-01-23
分类号C07J1;C07J17;C07J7;C07J3;C07J9;C07J21;C07J43;C07J31;C07J41;A61K31/58;A61K31/57;A61K31/56;A61K31/575;A61K31/5685;A61K31/568;A61K31/573;C07J5;C07J11;A61P21;A61P9/10;A61P25;A61P3;A61P1/16;A61P13/12;A61P3/10;A61P3/06;A61P9/08;A61P25/02;A61P27/02;A61P11/04;A61P25/14;A61P25/16;A61P25/28;A61P9;A61P9/04;A61P43;A61P29;A61P35;A61P31/18;C07J75;
国家 JP
入库时间 2022-08-21 14:44:02

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