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IDENTIFICATION OF CLONAL CELLS BY REPEAT SEQUENCES IN T-CELL RECEPTOR V/D/J GENES

机译:通过T细胞受体V / D / J基因的重复序列鉴定克隆细胞

摘要

PROBLEM TO BE SOLVED: To provide a method of characterizing a nucleic acid region and, more specifically, a method of analysing a marker nucleic acid region.SOLUTION: The method of the present invention is based on identification of one or both of the nucleic acid regions flanking a marker nucleic acid region and provides a means of analysing a marker nucleic acid region which is characteristic of a clonal population of cells. The method of the present invention is useful in the context of enabling a range of applications including, but not limited to, monitoring the progression of a condition characterized by the presence of a clonal population of cells (such as a neoplastic condition), monitoring the levels of one or more clonal cell populations, predicting the likelihood of a subject's relapse from a remissive state to a disease state, assessing the effectiveness of existing therapeutic drugs and/or new therapeutic agents and identifying the presence of a marker region.SELECTED DRAWING: None
机译:解决的问题:提供表征核酸区域的方法,更具体地,提供分析标记核酸区域的方法。解决方案:本发明的方法基于对一个或两个核酸的鉴定标记核酸区域侧翼的区域,并提供了分析标记核酸区域的手段,所述标记核酸区域是细胞克隆群体的特征。本发明的方法在实现一系列应用的情况下是有用的,包括但不限于监测以细胞克隆群的存在为特征的疾病的进展(例如赘生性疾病),监测肿瘤的发生。一个或多个克隆细胞群体的水平,预测受试者从缓解状态向疾病状态复发的可能性,评估现有治疗药物和/或新治疗药物的有效性以及确定标志物区域的存在。没有

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