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IDENTIFICATION OF CLONAL CELLS BY REPEAT SEQUENCES IN T-CELL RECEPTOR V/D/J GENES
IDENTIFICATION OF CLONAL CELLS BY REPEAT SEQUENCES IN T-CELL RECEPTOR V/D/J GENES
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机译:通过T细胞受体V / D / J基因的重复序列鉴定克隆细胞
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摘要
PROBLEM TO BE SOLVED: To provide a method of characterizing a nucleic acid region and, more specifically, a method of analysing a marker nucleic acid region.SOLUTION: The method of the present invention is based on identification of one or both of the nucleic acid regions flanking a marker nucleic acid region and provides a means of analysing a marker nucleic acid region which is characteristic of a clonal population of cells. The method of the present invention is useful in the context of enabling a range of applications including, but not limited to, monitoring the progression of a condition characterized by the presence of a clonal population of cells (such as a neoplastic condition), monitoring the levels of one or more clonal cell populations, predicting the likelihood of a subject's relapse from a remissive state to a disease state, assessing the effectiveness of existing therapeutic drugs and/or new therapeutic agents and identifying the presence of a marker region.SELECTED DRAWING: None
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