METHOD OF PREDICTING RESISTANCE TO INFECTIOUS DISEASES IN CHILD OF FIRST YEAR OF LIFE

摘要

FIELD: medicine.;SUBSTANCE: immunological indices in umbilical blood and venous blood on 4-5 day of life are determined. Resistance coefficient (Cres) is calculated by formula Cres=4.95258-0.0143955×(PI)+0.0962295×(PN)-0.00903362×(IgG)-0.257936×(IgA)-0.324514×(IgM)+0.430186×(CD45+CD3+)-1.66224×(CD45+CD4+CD3+)+l.49266×(CD45+CD8+CD3+)+0.815254×(CD4+CD8+)+0.522212×(HLA-DR+)-23.1991×(CD3+HLA-DR+)+0.974106×(CD3+CD25+)+0.832493×(CD3+CD4+CD25+)-3.52478×(CD16+CD56+CD3-)+7.67325×(CD16+CD56-CD3-)+11.082×(CD16+CD56+CD3+)+0.305366×(CD19+)+0.0691703×(CD5+)+0.0610707×(CD3+), where PI is phagocytic index, PN is phagocytic number, IgG, M, A are immunoglobulins of respective classes, CD are lymphocyte differentiation markers. If Cres value constitutes 1.78 and higher, when calculated by values of indices, obtained from umbilical blood, and is lower than 5.72, when counted by values of indices, obtained from venous blood on 4-5 day of life, on the first day of life high degree of resistance to infectious diseases is expected during the first year of life.;EFFECT: application of claimed method makes it possible to predict frequency of development of infectious diseases in child of the first year of life and take preventive measures to reduce risk of high morbidity.;2 tbl

机译：领域：医学;研究对象：确定生命4-5天脐带血和静脉血的免疫学指标。电阻系数（Cres）由公式Cres = 4.95258-0.0143955×（PI）+ 0.0962295×（PN）-0.00903362×（IgG）-0.257936×（IgA）-0.324514×（IgM）+ 0.430186×（CD45 + CD3 +）计算-1.66224×（CD45 + CD4 + CD3 +）+ 1.49266×（CD45 + CD8 + CD3 +）+ 0.815254×（CD4 + CD8 +）+ 0.522212×（HLA-DR +）-23.1991×（CD3 + HLA-DR +）+ 0.974106 ×（CD3 + CD25 +）+ 0.832493×（CD3 + CD4 + CD25 +）-3.52478×（CD16 + CD56 + CD3-）+ 7.67325×（CD16 + CD56-CD3-）+ 11.082×（CD16 + CD56 + CD3 +）+ 0.305366 ×（CD19 +）+ 0.0691703×（CD5 +）+ 0.0610707×（CD3 +），其中PI是吞噬指数，PN是吞噬数，IgG，M，A是各个类别的免疫球蛋白，CD是淋巴细胞分化标记。如果Cres值构成为1.78或更高（按脐带血获得的指标值计算），则低于5.72（按生命周期4-5天从静脉血获得的指标值计数）预期在生命的第一年中对感染性疾病具有高度的抵抗力;效果：所要求保护的方法的应用使得可以预测生命的第一年中儿童感染性疾病的发生频率并采取预防措施以降低风险高发病率。; 2汤匙

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公开/公告号RU2553356C1

专利类型
公开/公告日2015-06-10

原文格式PDF
申请/专利权人 GOSUDARSTVENNOE BYUDZHETNOE OBRAZOVATELNOE UCHREZHDENIE VYSSHEGO PROFESSIONALNOGO OBRAZOVANIYA VORONEZHSKAYA GOSUDARSTVENNAYA MEDITSINSKAYA AKADEMIYAIM. N.N. BURDENKO MINISTERSTVA ZDRAVOOKHRANENIYA ROSSIJSKOJ FEDERATSII;
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申请/专利号RU20140119155
发明设计人 LOGVINOVA IYA IVANOVNA;SKLYADNEVA KRISTINA ALEKSANDROVNA;
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申请日2014-05-13
分类号G01N33/53;
国家 RU
入库时间 2022-08-21 14:56:20

METHOD OF PREDICTING RESISTANCE TO INFECTIOUS DISEASES IN CHILD OF FIRST YEAR OF LIFE

摘要

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